Preferential Production of a Carbapenem Antibiotic, PS-5 by Dissolved Oxygen Controlled Fermentation

スポンサーリンク

概要

• 論文の詳細を見る

• As Streptomyces fulvoviridis A933-17M9 usually produces several carbapenem analogs including PS-5,the submerged fermentation conditions were optimized for preferential production of PS-5. The scale of PS-5 fermentation was expanded stepwise from a 2.5-l mini-jar fermentor to a 1500-l pilot-scale fermentor. For production of PS-5 as a major product among related carbapenem analogs, the concentration of dissolved oxygen during fermentation was controlled at levels where microbial conversion of PS-5 to epithienamycins A and C and further to MM177880 was largely prevented without deleterious influences on the carbapenem-biosynthesizing activity of mycelia.

• 社団法人日本生物工学会の論文
• 1990-07-25

著者

• OKAMOTO ROKURO

  Central Research Laboratories, Sanraku-Ocean Co., Ltd.,

• OKABE MITSUYASU

  Department of Applied Biological Chemistry, Faculty of agriculture, Shizuoka University

• Kubo Kanako

  Department Of Applied Chemistry And Chemical Engineering Faculty Of Engineering Yamaguchi University

• Okabe Mitsuyasu

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• Okabe Mitsuyasu

  Mercian Co. Central Research Laboratories

• Okabe Mitsuyasu

  Biotechnology Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Univer

• Okabe Mitsuyasu

  Laboratory Of Biotechnology Faculty Of Agriculture Shizuoka University

• Okabe Mitsuyasu

  Biochemical Engineering Laboratory Department Of Applied Biological Chemistry Faculty Of Agriculture

• Okabe Mitsuyasu

  (present Address)department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University

• OKAMURA Kazuhiko

  Central Research Laboratories, Mercian Corporation

• Azuma Shoji

  Central Research Laboratories Sanraku Incorporated

• Kojima I

  Mercian Corporation Central Research Laboratories

• Fukagawa Yasuo

  Bristol-myers Squibb Research Institute Ltd. Tokyo Research Center

• Fukagawa Yasuo

  Central Research Laboratories Sanraku Incorporated

• Okamoto R

  Mercian Corp. Fujisawa Jpn

• KUBO KATSURO

  Central Research Laboratories, Merican Corporation

• Okabe M

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• Kubo K

  Department Of Applied Chemistry And Chemical Engineering Faculty Of Engineering Yamaguchi University

• Kubo Katsuro

  Central Research Laboratories Merican Corporation

• Okamura Kazuhiko

  Central Research Laboratories Sanraku Incorporated

• Okamura Kazuhiko

  Central Research Laboratories Mercian Corporation

• KOJIMA IKUO

  Central Research Laboratories, Sanraku Incorporated

• TAKADA KAZUO

  Central Research Laboratories, Sanraku Incorporated

• MUTOH YOSHIFUMI

  Central Research Laboratories, Sanraku Incorporated

• ISHIKURA TOMOYUKI

  Central Research Laboratories, Sanraku Incorporated

• Okamoto Rokuro

  Central Research Laboratories Mercian Corporation

• Mutoh Yoshifumi

  Central Research Laboratories Sanraku Incorporated

• Ishikura Tomoyuki

  Central Research Laboratories Sanraku Incorporated

• Okamura Kazuhiko

  Central Research Laboratories Mercian Co. Ltd.

• Takada Kazuo

  Central Research Laboratories Sanraku Incorporated

• Okamura Kazuhiko

  Central Research Laboratories Marcian Corp.

関連論文

• Isolation of Methanol-assimilating Bacteria and Optimum Medium Composition
• Optimization of Tylosin Feeding Rate Profile in Production of Acetyl-Isovaleryl Tylosin(AIV)from Tylosin by Streptomyces thermotolerans YN554
• Effect of Soybean Oil on Oxygen Transfer in the Production of Tetracycline with an Airlift Bioreactor
• Enhancement of Yeast Fermentation by Addition of Oxygen Vectors in Air-Lift Bioreactor
• Effect of Nitrogen Source on Mycelial Morphology and Arachidonic Acid Production in Cultures of Mortierella alpina
• Image Analysis of Morphological Change during Arachidonic Acid Production by Mortierella alpina 1S-4
• Mycelial Pellet Intrastructure Visualization and Viability Prediction in a Culture of Streptomycese fradiae Using Confocal Scanning Laser Microscopy
• Change of Mycelial Morphology in Tylosin Production by Batch Culture of Streptomyces fradiae under Various Shear Conditions
• Effect of Culture Temperature and Dissolved Oxygen Concentration on Expression of α-Amylase Gene in Batch Culture of Spore-Forming Host, Bacillus subtilis 1A289
• Mer-A2026A and B, Novel Piericidins with Vasodilating Effect II.Physico-Chemical Properties and Chemical Structures
• Mer-A2026A and B, Novel Piericidins with Vasodilating Effect I.Producing Organism, Fermentation, Isolation and Biological Properties
• Production of Levanbiose by a Levan-degrading Enzyme from Streptomyces exfoliatus F3-2
• A New Type of Streptomycete Arylsulfatase with High Affinity to the Sulfuryl Moiety of the Substrate
• Arylsulfatase from Streptomyces griseorubiginosus S980-14
• Screening and Production of Arylsulfatases for Target Therapy with Etoposide 4'-Sulfate,an Antitumor Prodrug
• Isolation of Five Laccase Gene Sequences from the White-Rot Fungus Trametes sanguinea by PCR, and Cloning, Characterization and Expression of the Laccase cDNA in Yeasts
• Copper-Dependent Production of a Pycnoporus coccineus Extracellular Laccase in Aspergillus oryzae and Saccharomyces cerevisiae
• Oxidative Decarboxylations of 4-Hydroxymandelic Acid and 2-(4-Hydroxyphenyl)glycine by Laccase from Coriolus versicolor and Bilirubin Oxidases from Trachyderma tsunodae and Myrothecium verrucaria
• Transformation of 7-(4-Hydroxyphenylacetamido)cephalosporanic Acid into a New Cephalosporin Antibiotic, 7-[1-Oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carboxamido]ceph-alosporanic Acid, by Laccase
• Coriolus versicolor Laccase Catalyzes the Decarboxylation of 2-(4-Hydroxyphenyl)-glycine and 4-Hydroxymandelic Acid
• Kojic Acid Production in an Airlift Bioreactor Using Partially Hydrolyzed Raw Corn Starch
• Daunomycin Biosynthesis by Microbial Conversion of Precursor Metabolited Using Biosynthetically Blocked Mutants
• Production of ε-Polylysine in an Airlift Bioreactor (ABR)
• Enhancement of ε-Polylysine Production by Streptomyces albulus Strain 410 Using pH Control
• Analysis of Sensitivity to High Temperature of Torulaspora delbrueckii No.3110
• Accumulation and Role of Trehalose in Torulaspora delbrueckii No.3110
• Production of L-Lactic Acid from Corncob (BIOCHEMICAL ENGINEERING)
• Continuous Beer Fermentation by High Cell-Density Culture of Bottom Brewer's Yeast
• Scaleup of Peroxidase Production by Arthromyces ramosus/Based on Analysis of Fluid Velocity Distribution
• Growth and Fermentation Characteristics of Bottom Brewer's Yeast under Mechanical Stirring
• Scale-Up of L-Lactic Acid Production by Mutant Strain Rhizopus sp. MK-96-1196 from 0.003m^3 to 5m^3 in Airlift Bioreactors(BIOCHEMICAL ENGINEERING)
• 2D10-5 Production of itaconic acid using Indonesia sago starch by Aspergillus terreus TN484-M1
• Enhanced Production of L-Lactic Acid by Ammonia-Tolerant Mutant Strain Rhizopus sp. MK-96-1196
• Optimization and Scale-Up of L-Lactic Acid Fermentation by Mutant Strain Rhizopus sp. MK-96-1196 in Airlift Bioreactors (BIOCHEMICAL ENGINEERING)
• Improvement of Production of Kojic Acid by a Mutant Strain Aspergillus oryzae, MK107-39
• L(+)-Lactic Acid Production by Repeated Batch Culture of Rhizopus oryzae in Air-Lift Bioreactor
• Efficient Itaconic Acid Production from Raw Corn Starch
• Enhanced Production of L(+)-Lactic Acid from Corn Starch in a Culture of Rhizopus oryzae Using an Air-Lift Bioreactor
• Optimization of Conditions for Conversion of Tylosin to a Novel Antibiotic, Acetyl-Isovaleryl Tylosin (AIV), by Streptomyces thermotolerans and Scale-Up to 200-Liter Pilot-Scale Fermentor
• 2G09-3 Isolation of Ammonia-Tolerant L-Lactic Acid Producing Mutant Strain Rhizopus sp. MK-96-1196
• Direct Fermentative Production of Acyltylosins by Genetically-engineered Strains of Streptomyces fradiae
• Cloning and Nucleotide Sequences of Two Genes Involved in the 4''-O-Acylation of Macrolide Antibiotics from Streptomyces thermotolerans
• Preferential Production of a Carbapenem Antibiotic, PS-5 by Dissolved Oxygen Controlled Fermentation
• Application of Cyclodextrin to Microbial Transformation of Vitamin D_3 to 25-Hydroxyvitamin D_3 and 1α, 25-Dihydroxyvitamin D_3
• Preferential and High-Yield Production of a Cephamycin C by Dissolved Oxygen Controlled Fermentation
• Flow Characteristic Simulation for Tower Fermentor With Two-fluid Nozzle : Studies on Biomass Production from Methanol (V)
• Growth Characteristics of Marine Methanol-utilizing Bacteria : Studies on Marine Methanol-utilizing Bacteria(II)
• Fermentative Production of Deltamycin and Deacyldeltamycin : Presented at the Annual Meeting of the Society of Fermentation Technology of Japan, Osaka, October 25,1976.
• Siamycins I and II, New Anti-HIV Peptides:I.Fermentation, Isolation, Biological Activity and Initial Characterization
• Deacetylation of PS-5,a New β-Lactam Compound-3-Enzymological Characterization of L-Amino Acid Acylase and D-Amino Acid Acylase from Pseudomonas sp. 1158
• Deacetylation of PS-5,a New β-Lactam Compound-2-Separation and Purification of L- and D-Amino Acid Acylases from Pseudomonas sp. 1158
• Enhanced Production of Antibiotics by Pecilomyces lilacinus under Alkaline Conditions Associated with Morphological Change(Microbiology & Fermentation Industry)
• Isolation and Characterization of Marine Methanol-utilizing Bacteria : Studies on Marine Methanol-utilizing Bacteria(I)
• Comparison of Neomycin Production from Streptomyces fradiae Cultivation Using Soybean Oil as the Sole Carbon Source in an Air-Lift Bioreactor and a Stirred-Tank Reactor
• Neomycin Production by Partial Immobilization Streptomyces fradiae on Cellulose Beads in an Air-Lift Bioreactor
• Itaconic Acid Production in an Air-Lift Biorector Using a Modified Draft Tube
• Nucleotide Sequence Analysis of the Carbomycin Biosynthetic Genes Including the 3-O-Acyltransferase Gene from Streptomyces thermotolerans
• A Novel Process of Cyclodextrin Production by the Use of Specific Adsorbents : Part II. A New Reactor System for Selective Production of α-Cyclodextrin with Specific Adsorbent
• A Novel Process of Cyclodextrin Production by the Use of Specific Adsorbents : Part I. Screening of Specific Adsorbents
• Breeding of Aspergillus terreus Mutant TN-484 for Itaconic Acid Production with High Yield
• Improvement of Cephamycin C Production by a Mutant Resistant to Linoleic Acid
• A Novel Pyrazine Compound Produced from Chitin by the Activity of the Enzyme from Vibrio alginolyticus TK-24
• New Anthracycline Antibiotic CG12 Obtained by Microbial Glycosidation of α-Citromycinone
• A Highly Active Producer of Coproporphyrin III and Uroporphyrin III
• Identification of Porphyrins Produced from Isopropanol by Arthrobacter hyalinus
• Vitamin B_ Production by Isopropanol-Assimilating Microorganisms
• IMMUNOLOGICAL CROSS-REACTIVITIES OF VARIOUS ANTHRACYCLINE ANTIBIOTICS AGAINST ACLACINOMYCIN A ANTISERA
• A New Biosynthetic Pathway of Prophyrins from Isopropanol
• Cloning of Stress Tolerance Gene in Torulaspora delbrueckii No. 3110
• An Improved Radioimmunoassay for Guanosine-5 -diphosphate-3 - diphosphate (ppGpp) and Its Application to Search for ppGpp in Rat Embryo and Brain
• Neoviridogrisein-Cls, NewAnalogs of Viridogrisein, Produced under the Supplementation of 4-Chloro-L-proline
• Carbon Catabolite Regulation of Neoviridogrisein Production by Glucose
• A Possible Biosynthetic Precursor of 3-Hydroxypicolinic Acid in Etamycin
• Influence of Methylproline Isomers upon Neoviridogrisein Synthesis
• A Certain Mutant Blocked in trans-4-Hydroxy-L-proline Formation from L-Proline during Neoviridogrisein Biosynthesis
• Some Effectors on the Biosynthesis of cis-4-Hydroxy-D-proline in Viridogrisein
• Determination of CGTase from Bacillus ohbensis and Its Optimum pH Using HPLC

もっと見る 閉じる

スポンサーリンク