Improvement of Cephamycin C Production by a Mutant Resistant to Linoleic Acid

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概要

• 論文の詳細を見る

• Streptomyces sp. P6621 was very sensitive to linoleic acid when soybean oil was used as the sole carbon source for the production of cephamycin C. Cell growth was strictly restrained by adding 0.25 g/l of linoleic acid to the culture. An ultraviolet-induced mutation was performed based on the hypothesis that a mutant resistant to linoleic acid could produce antibiotics more efficiently. Mutant strain U-12-2 resistant to 0.4 g/l of linoleic acid was obtained by screening in solid and liquid media containing linoleic acid. The uptake rate of linoleic acid by U-12-2 was three times higher than that by the parental strain. Cephamycin C production from 30 and 60 g/l of soybean oil as the sole carbon source was 1.6 fold higher with the mutant strain compared to the parental strain. It is concluded that this mutant which is resistant to linoleic acid has improved cephamycin C production.

• 社団法人日本生物工学会の論文
• 1994-07-25

著者

• Park Y

  Shizuoka Univ. Shizuoka Jpn

• Park Yong

  Biochemical Engineering Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizu

• Park Yong

  (present Address)department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Universi

• Park Yong

  Biochemical Eng. Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Uni

• OKABE MITSUYASU

  Department of Applied Biological Chemistry, Faculty of agriculture, Shizuoka University

• OKABE MITSUYASU

  Biochemical Engineering Laboratory, Department of Applied Biological Chemistry, Faculty of Agricultu

• Okabe Mitsuyasu

  Biochemical Eng. Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Uni

• Okabe Mitsuyasu

  Mercian Co. Central Research Laboratories

• Okabe Mitsuyasu

  Biotechnology Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Univer

• Okabe Mitsuyasu

  Laboratory Of Biotechnology Faculty Of Agriculture Shizuoka University

• Okabe Mitsuyasu

  Biochemical Engineering Laboratory Department Of Applied Biological Chemistry Faculty Of Agriculture

• Okabe Mitsuyasu

  (present Address)department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University

• Okabe M

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• YAHIRO KAZUTOYO

  United Graduate School of Agricultural Science, Gifu University

• INOUE KOUJI

  Biochemical Engineering Lab., Department of Applied Biological Chemistry, Faculty of Agriculture, Sh

• Yahiro Kazutoyo

  Department Of Development Chikou Co. Ltd.

• Inoue Kouji

  Biochemical Engineering Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizu

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