Efficient Tylosin Production from Streptomyces fradiae Using Rapeseed Oil

概要

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Tylosin production in flask and jar fermentor culture of Streptomyces fradiae using seven different vegetable oils as sole carbon sources was investigated. Among the vegetable oils, rapeseed oil was the best carbon source for tylosin production. When the initial rapessed oil concentration was 60 g/l, the maximum tylosin concentration reached was 7.0 g/l, which was about 1.6- and 7-fold that reached using starch and glucose, respectively, at the same initial concentration. Although oil consumption increased with increasing agitation rate, the highest tylosin yield was obtained using an agitation rate of 400 rpm. This indicates that in the case of using an insoluble carbon source, use of an appropriate agitation rate is important for efficient production of tylosin.
社団法人日本生物工学会の論文
1996-08-25