Optimization of Conditions for Conversion of Tylosin to a Novel Antibiotic, Acetyl-Isovaleryl Tylosin (AIV), by Streptomyces thermotolerans and Scale-Up to 200-Liter Pilot-Scale Fermentor

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概要

• 論文の詳細を見る

• The rate of substrate (tylosin) supply, pH, dissoleved oxygen concentration, and temeprature for bioconversion of tylosin to acetyl-isovaleryl tylosin (AIV), were optimized in a flask and a 3-l jar fermentor. An AIV concentration 9.3 g/l was achieved when the pH was controlled at 7.0 and the tylosin supply rate was maintained at 200 mg/l/h during the period of bioconversion of tylosin to AIV after the cell growth phase. Based on the data obtained for the flask and jar-fermentor cultures, the bioconversion process was successfully scaled up to a 200-l fermentor. In this pilot-scale fermentor, 13.8 g/l of AIV was obtained at a yield of 83% based on the amount of tylosin supplied.

• 社団法人日本生物工学会の論文
• 1997-07-25

著者

• HUANG GUOWEI

  United Graduate School of Agricultural Science, Gifu University

• PARK YONGSOO

  Biochemical Engineering Laboratory, Department of Applied Biological Chemistry, Faculty of Agricultu

• OKABE MITSUYASU

  Biochemical Engineering Laboratory, Department of Applied Biological Chemistry, Faculty of Agricultu

• Okabe Mitsuyasu

  Biochemical Eng. Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Uni

• Okabe Mitsuyasu

  Mercian Co. Central Research Laboratories

• Okabe Mitsuyasu

  Biotechnology Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Univer

• Okabe Mitsuyasu

  Laboratory Of Biotechnology Faculty Of Agriculture Shizuoka University

• Okabe Mitsuyasu

  Biochemical Engineering Laboratory Department Of Applied Biological Chemistry Faculty Of Agriculture

• Okabe Mitsuyasu

  (present Address)department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University

• Huang G

  United Graduate School Of Agricultural Science Gifu University

• Huang Guowei

  United Graduate School Of Agricultural Science Gifu University

• Park Y

  Laboratory Of Biotechnology Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuo

• Okamoto Rokuro

  Process Development Lab. Mercian Corporation

• Okabe M

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• HIKITA ATSUSHI

  Biochemical Engineering Lab., Department of Applied BIological Chemistry, Faculty of Agriculture, Sh

• Hikita Atsushi

  Biochemical Engineering Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizu

関連論文

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