Preferential and High-Yield Production of a Cephamycin C by Dissolved Oxygen Controlled Fermentation

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概要

• 論文の詳細を見る

• Streptomyces sp. P6621-RS1726,a high cephamycin C producing mutant, usually produces cephamycin C together with its precursor, penifillin N, in flask fermentation. The fermentation conditions for selective and high yield production of cephamycin C were investigated using 20-l jar fermentors. As a result, cephamycin C was preferentially produced without penicillin N when the DO level was maintained at least higher than at 10% during the production phase. However, when the agitation speed was too high at the initial stage of the fermentation, the cell growth was inhibited, resulting in suppression of both cephamycin C and penicillin N production, even if the DO was maintained at a high level. Based on these experiments, a computer control system for preferential and high-yield production of cephamycin C was constructed. By using this computer control system, scale-up from a 20-l jar fermentor to a 1,500-l pilot fermentor was carried out with control of the DO level at 20% of saturation during the cephamycin C production phase. As a result, the profile of cephamycin C production in the former was favorably reproduced in the latter.

• 社団法人日本生物工学会の論文
• 1992-04-25

著者

• OKAMOTO ROKURO

  Central Research Laboratories, Sanraku-Ocean Co., Ltd.,

• OKABE MITSUYASU

  Department of Applied Biological Chemistry, Faculty of agriculture, Shizuoka University

• Kubo Kanako

  Department Of Applied Chemistry And Chemical Engineering Faculty Of Engineering Yamaguchi University

• Okabe Mitsuyasu

  Mercian Co. Central Research Laboratories

• Okabe Mitsuyasu

  Biotechnology Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Univer

• Okabe Mitsuyasu

  Laboratory Of Biotechnology Faculty Of Agriculture Shizuoka University

• Okabe Mitsuyasu

  Biochemical Engineering Laboratory Department Of Applied Biological Chemistry Faculty Of Agriculture

• Okabe Mitsuyasu

  (present Address)department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University

• OKAMURA Kazuhiko

  Central Research Laboratories, Mercian Corporation

• Okamura K

  Advanced Technology Research Department Institute Of Technology Shimizu Corporation

• Okamura K

  Mercian Corporation Central Research Laboratories

• Okamoto R

  Mercian Corp. Fujisawa Jpn

• Okabe M

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• Kubo K

  Department Of Applied Chemistry And Chemical Engineering Faculty Of Engineering Yamaguchi University

• Okamura K

  Mercian Corp. Kanagawa Jpn

• Okamura Kazuhiko

  Central Research Laboratories Sanraku Incorporated

• Okamura Kazuhiko

  Central Research Laboratories Mercian Corporation

• KIMURA KIYOSHI

  Central Research Laboratories, Mercian Corp.,

• KUWAJIMA TAKESHI

  Central Research Laboratories, Mercian Co. Ltd.,

• SATOH MICHIKATSU

  Central Research Laboratories, Mercian Co. Ltd.,

• Okamoto Rokuro

  Central Research Laboratories Mercian Corporation

• Kuwajima Takeshi

  Central Research Laboratories Mercian Co. Ltd.

• Okamura Kazuhiko

  Central Research Laboratories Marcian Corp.

• Satoh M

  Nihon Univ. Kanagawa Jpn

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