Transformation of 7-(4-Hydroxyphenylacetamido)cephalosporanic Acid into a New Cephalosporin Antibiotic, 7-[1-Oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carboxamido]ceph-alosporanic Acid, by Laccase

スポンサーリンク

概要

• 論文の詳細を見る

• 7-(4-Hydroxyphenylacetamido)cephalosporanic acid (1) was transformed into 7-[1-oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carbox-amido]cephalosporanic acid (2) by laccase-catalyzed phenolic oxidation. 2 consisted of two diastereomers, named CXL-1 and CXL-2. CXL-2 was 10-30 times more active than CXL-1, although less active than 1.

• 社団法人日本農芸化学会の論文
• 1993-08-23

著者

• Nishida Hiroshi

  Department Of Cardiovascular Surgery The Heart Institute Of Japan Tokyo Women's Medical Univers

• YOSHIOKA Takeo

  Central Research Laboratories, Mercian Corp.

• OKAMOTO ROKURO

  Central Research Laboratories, Sanraku-Ocean Co., Ltd.,

• Murao Sawao

  Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture

• Murao S

  Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology

• Murao S

  Department Of Applied Biological Chemistry College Of Agriculture University Of Osaka Prefecture

• SHIN Takashi

  Department of Applied Microbial Technology, The Kumamoto Institute of Technology

• AGEMATU Hitosi

  Central Research Laboratories, Mercian Corporation

• KOMINATO Kaichiro

  Central Research Laboratories, Mercian Corporation

• Murao S

  Sojo Univ. Kumamoto Jpn

• Murao Sawao

  Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture

• Shin T

  Department Of Applied Microbial Technology The Kumamoto Institute Of Technology

• Shin Takashi

  Department Of Applied Microbial Technology Kumamoto Institute Of Technology

• Agematu Hitosi

  Central Research Laboratories Mercian Corporation

• Okamoto R

  Mercian Corp. Fujisawa Jpn

• Yoshioka Takeo

  Central Research Laboratories Mercian Corporation

• Nishida H

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Shibamoto Norio

  Central Research Laboratories, Mercian Co.

• Nishida Hiroshi

  Central Research Laboratories, Mercian Co.

• Shibamoto Norio

  Central Research Laboratories Mercian Co.

• Nishida H

  Department Of Cardiovascular Surgery The Heart Institute Of Japan Tokyo Women's Medical Univers

• Agematu Hitosi

  Central Research Laboratories Mercian Co.

• Agematu H

  Mercian Corp. Fujisawa Jpn

• Okamoto Rokuro

  Central Research Laboratories Mercian Corporation

• Takenisi Shigeyuki

  Osaka Municipal Technical Research Institute

• Kominato Kaichiro

  Central Research Laboratories Mercian Corporation

• Nishida Hiroshi

  Central Research Laboratories Sanraku-ocean Co. Ltd.

• Yoshioka Takeo

  Central Research Laboratories, Mercian Corporation

• SHIN Takashi

  Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture

関連論文

• Successful treatment of a patient with severe pulmonary hypertension due to perivalvular leakage at aortic and mitral positions after aortic and mitral valve replacement
• Geographical Distribution of the Lung Fluke, Paragonimus westermani-diploid type (Trematoda, Troglotrematidae) in the Northern Part of Okayama Prefecture, Japan
• Theoretical Prediction of Shear Strength Evolution in Steel Fibre Reinforced Concrete Beams without Stirrups
• Synthesis and Biological Evaluation of Cytogenin Derivatives
• Mer-f3,12-Hydroxy-ovalicin, Produced by Metarrhizium sp. f3
• Inhibition of Angiogenesis by a New Isocoumarin, NM-3
• Isolation of Methanol-assimilating Bacteria and Optimum Medium Composition
• Corrosion of stainless steel sternal wire after long-term implantation
• Left Ventricular True Aneurysm with Pseudoaneurysm Detected Five Years and Nine Months Following Repair for Oozing Type Free Wall Rupture
• Left Ventricular Mass Index Reduction Early after an Isolated Aortic Valve Replacement with St. Jude Medical 19A-HP
• Sequential Bypass Using the Right Gastroepiploic Artery for Coronary Artery Bypass Grafting
• Acute Occlusion of Coronary Artery Bypass Graft With Nonionic Contrast Medium
• Off-Pump Reimplantation of Anomalous Origin of the Right Coronary Artery
• Current circulatory support with step-by evaluation of biventricular and pulmonary function
• Surgery of Ascending Aorta and/or Aortic Arch Using Deep Hypothermic Circulatory Arrest with Retrograde Cerebral Perfusion and Open Technique
• New Graft Holder for Coronary Artery Bypass Using Arterial Conduits
• Use of Arterial Grafts for Coronary Revascularization : Experience of 2987 Anastomoses
• EVALUATION OF GASTROEPIPLOIC ARTERY BYPASS GRAFT FLOW USING DUPLEX DOPPLER ECHOCARDIOGRAPHY
• Surgery for Complications Due to Myocardial Infarction : 50th Annual Scientific Session of the Japanese Circulation Society
• -361- "EPICARDIAL APPROACH" FOR WPW SYNDROME (TYPE A) WITHOUT CARDIOPULMONARY BYPASS
• -241- LONG-TERM RESULTS OF INTERNAL MAMMARY ARTERY GRAFTING TO LEFT ANTERIOR DESCENDING ARTERY : COMPARISON WITH SAPHENOUS VEIN GRAFTING : PTCA, CABG : FREE COMMUNICATIONS(II) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION
• MITRAL VALVE PROLAPSE : REVIEW OF 167 CASES : Valvular Heart Disease : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• RETROSPECTIVE COMPARATIVE STUDY OF CABG, PTCA AND MEDICAL TREATMENT IN LAD SINGLE VESSEL DISEASE : PTCA, Thrombosis : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• -279-SURGICAL THERAPY FOR VENTRICULAR TACHYCARDIA/FIBRILLATION ASSOCIATED WITH VENTRICULAR ANEURYSM
• ENHANCEMENT OF INDICATION OF CORONARY SURGERY : RESULTETS OF SURGICAL OPERATION IN 101 CASES OF LESS THAN 35% OF EF : Ischemic Heart Disease (IV) : FREE COMMUNICATIONS (IV) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SO
• CORONARY ARTERY BYPASS GRAFTING IN PATIENTS WITH EJECTION FRACTIONS BELOW 0.35 : Ischemic Heart Disease (II), Coronary Circulation : II : 48 Annual Scientific Meeting, Japanese Circulation Society
• Clinical applications of assisted circulation : new trends and future aspects
• OJ-118 Beneficial Impact of Exclusive Use of In Situ Arterial Conduits over Combined Use of Saphenous Vein Grafts for Multiple CABG(Cardiovascular Surgery/CABG 1 (IHD) : OJ15)(Oral Presentation (Japanese))
• 1 Myocardial Revascularization in Patients with Diabetes Mellitus(Symposium 7 (SY7) (IHD) : Longterm Prognosis of Japanese Patients with Coronary Disease : Medical Therapy, PCI, Surgical Intervention)(Special Program)
• Epoxyquinomicins A, B, C and D, New Antibiotics from Amycolatopsis II. Effect on Type II Collagen-induced Arthritis in Mice
• Acetoxydehydroaustin, a New Bioactive Compound, and Related Compound Neoaustin from Penicillium sp. MG-11
• Identification of the Microorganism Which Produces Epstein-Barr Virus Early Antigen-inducing Indole Alkaloids
• Shengmai-san Enhances Antioxidant Potential in C2C12 Myoblasts Through the Induction of Intracellular Glutathione Peroxidase
• Streptomyces Pepsin Inhibitor-insensitive Carboxyl Proteinase from Ganoderma lucidum
• Streptomyces Pepsin Inhibitor-Insensitive Carboxyl Proteinase from Lentinus edodes
• Purification and Some Properties of Carboxyl Proteinase in Mycelium of Lentinus edodes
• A CLN2-Related and Thermostable Serine-Carboxyl Proteinase, Kumamolysin: Cloning, Expression, and Identification of Catalytic Serine Residue
• Nucleotide Sequence of the Gene Encoding Pepstatin-insensitive Acid Protease B, Scytalidopepsin B, of Scytalidium lignicolum
• A Novel Laccase Inhibitor, N-Hydroxyglycine, Produced by Penicillium citrinum YH-31
• New Enzymatic Colorimetric Analyses to Evaluate the Activities of Carboxypeptidase A and B(Analytical Chemistry)
• A New Screening Method for Microorganisms Which Produce Carboxypeptidases
• New Enzymatic Colorimetric Reactions of Benzoic Acid Derivatives with ABTS [2, 2-Azino-di-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt] in the Presence of Laccase
• Purification and Some Properties of Urethane Hydrolase II from Lactobacillus casei ε ATCC 7469
• Isolation and Characterization of N^α-Benzyloxycarbonyl Amino Acid Urethane Hydrolase II from Lactobacillus fermenti 36 ATCC 9338(Biological Chemistry)
• Structures of the Laccase-catalyzed Oxidation Products of Hydroxy-benzoic Acids in the Presence of ABTS [2,2'-Azino-di-(3-ethylbenzothiazoline-6-sulfonic Acid)]
• Baicalin Promoted the Repair of DNA Single Strand Breakage Caused by H_2O_2 in Cultured NIH3T3 Fibroblasts
• A Simultaneous Assay Method for L-Glutamate and L-Pyroglutamate Contents in Soy Sauce Using a 5-Oxoprolinase (without ATP Hydrolyzing Activity)
• Nucleotide Sequence of the Gene Encoding the Precursor Protein of Pepstatin insensitive Acid Protease B, Scytalidopepsin B, from Scytalidium lignicolum
• Purification and Characterization of a Prolyl Endopeptidase from Pseudomonas sp. KU-22
• Isolation and Characterization of a Novel 5-Oxoprolinase (without ATP-hydrolyzing)from Alcaligenes faecalis N-38A
• Isolation and Characterization of a Dipeptidyl Aminopeptidase from Streptomyces sp.WM-23
• Purification and Characterization of Arctium lappa L. (Edible Burdock) Polyphenol Oxidase
• Enhancement of Activities of Cellulases under High Hydrostatic Pressure
• Isolation and Identification of a Pyrogallol Oxidase Producing Microorganism and the Enzyme Production
• Purification and Properties of Three Xylanases from Aspergillus aculeatus
• Rhodopeptins(Mer-N1033), Novel Cyclic Tetrapeptides with Antifungal Activity from Rhodococcus sp. 1. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities
• Mer-A2026A and B, Novel Piericidins with Vasodilating Effect II.Physico-Chemical Properties and Chemical Structures
• Mer-A2026A and B, Novel Piericidins with Vasodilating Effect I.Producing Organism, Fermentation, Isolation and Biological Properties
• Amyloid-β-Induced Cytotoxicity of PC-12 Cell Was Attenuated by Shengmai-san Through Redox Regulation and Outgrowth Induction
• Oxidative Decarboxylations of 4-Hydroxymandelic Acid and 2-(4-Hydroxyphenyl)glycine by Laccase from Coriolus versicolor and Bilirubin Oxidases from Trachyderma tsunodae and Myrothecium verrucaria
• Transformation of 7-(4-Hydroxyphenylacetamido)cephalosporanic Acid into a New Cephalosporin Antibiotic, 7-[1-Oxaspiro(2.5)octa-6-oxo-4, 7-diene-2-carboxamido]ceph-alosporanic Acid, by Laccase
• Coriolus versicolor Laccase Catalyzes the Decarboxylation of 2-(4-Hydroxyphenyl)-glycine and 4-Hydroxymandelic Acid
• Isolation and Characterization of a Proteinaceous Protease Inhibitor from Bacillus subtilis(Microbiology & Fermentation Industry)
• Additional Evidence for the Identity of Scytalidium lignicolum Acid Proteinases with the Carboxyl Proteinase Group : The Interaction between Angiotensin I and S-PI-Insensitive Acid Proteinases by Means of A Zinc(II)-Dye Complex as a Probe(Biological Chemi
• Characterization of the Complex between α_2-Macroglobulin and a Serine Proteinase from Bacillus natto(Biological Chemistry)
• Comparative Study on the Specificities of Several Fungal Aspartic and Acidic Proteinases towards the Tetradecapeptide of a Renin Substrate(Biological Chemistry)
• Carboxyl Proteinase Essential for Maturation of Basidiospores of Lentinus edodes (shiitake)
• Sextuple Coronary Artery Bypass Grafting Using Only in situ Arterial Conduits
• Purification and Characterization of a Novel Type of Chitinase from Vibrio alginolyticus TK-22
• Purification and Characterization of an Alkaline Proteinase Produced by Pimelobacter sp. Z-483
• Isolation of Propioxatin A from Actinosynnema sp. SI-23 during a Screening for Serratia piscatorum Metalloproteinase Inhibitors
• Purification and Properties of an S-PI(Pepstatin Ac)-insensitive Carboxyl Proteinase from a Xanthomonas sp. Bacterium(Biological Chemistry)
• Stresgenin B, an Inhibitor of Heat-induced Heat Shock Protein Gene Expression, Produced by Streptomyces sp. AS-9
• Rhodopeptins, Novel Cyclic Tetrapeptides with Antifungal Activities from Rhodococcus sp. III. Synthetic Study of Rhodopeptins
• Rhodopeptins, Novel Cyclic Tetrapeptides with Antifungal Activities from Rhodococcus sp. II. Structure Elucidation
• Molecular Characterization of a Rhodotorula-lytic Enzyme from Paecilomyces lilacinus Having β-1, 3-Mannanase Activity
• Biosynthesis of (2R)-4-Amino-2-hydroxybutyric Acid, Unique and Biologically Significant Substituent in Butirosins
• Interaction of Proteinaceous Protease Inhibitor of Bacillus subtilis with Intracellular Proteases from the Same Strain(Microbiology & Fermentation Industry)
• CURRENT STATUS AND EVALUATION OF TRANSNASAL ESOPHAGOGASTRODUODENOSCOPY
• Novel β-D-Galactofuranose-containing High-mannose Type Oligosaccharides in Ascorbate Oxidase from Acremonium sp. HI-25
• Properties of Ascorbate Oxidase Produced by Acremonium sp. HI-25
• Isolation and Purification of Ascorbate Oxidase from Acremonium sp.HI-25
• An Acidic Ascorbate Oxidase Produced by Acremonium sp. HI-25(Biological Chemistry)
• Different Action by Two Avicelases from Aspergillus aculeatus(Biological Chemistry)
• Reduced Cellulose as a Substrate of Cellulases(Biological Chemistry)
• Enzymatic Properties of Hydrocellulase from Aspergillus aculeatus
• A Novel Thermostable, S-PI(Pepstatin Ac)-insensitive Acid Proteinase from Thermophilic Bacillus novosp. Strain MN-32(Biological Chemistry)
• Secretive Expression of the Aspergillus aculeatus Cellulase (FI-CMCase) by Saccharomyces cerevisiae
• Expression of the Cellulase (FI-CMCase) Gene of Aspergillus aculeatus in Saccharomyces cerevisiae
• Colorimetric Measurement of Total Activity of Leucine Aminopeptidase and Arylamidase in Serum Using Laccase-Catalyzed Oxidative Decarboxylation
• Preferential Production of a Carbapenem Antibiotic, PS-5 by Dissolved Oxygen Controlled Fermentation
• Application of Cyclodextrin to Microbial Transformation of Vitamin D_3 to 25-Hydroxyvitamin D_3 and 1α, 25-Dihydroxyvitamin D_3
• Preferential and High-Yield Production of a Cephamycin C by Dissolved Oxygen Controlled Fermentation
• Flow Characteristic Simulation for Tower Fermentor With Two-fluid Nozzle : Studies on Biomass Production from Methanol (V)
• Growth Characteristics of Marine Methanol-utilizing Bacteria : Studies on Marine Methanol-utilizing Bacteria(II)
• Enhanced Production of Antibiotics by Pecilomyces lilacinus under Alkaline Conditions Associated with Morphological Change(Microbiology & Fermentation Industry)
• Isolation and Characterization of Marine Methanol-utilizing Bacteria : Studies on Marine Methanol-utilizing Bacteria(I)
• Effect of a Sudden Change in Feeding of Forages with DifferentQualities on Dry-Matter Intake and Behavioral Pattern of Sheep
• Isolation of New Anthracyclines 10-O-Rhodosaminyl β-Rhodomycinone and β-Isorhodomycinone form Mild-acid Treated Culture of Obelmycin-producing Streptomyces violaceus
• New Betaclamycin and Aclarubicin Analogs Obtained by Prolonged Microbial Conversion with an Aclarubicin-negative Mutant

もっと見る 閉じる

スポンサーリンク