Application of Cyclodextrin to Microbial Transformation of Vitamin D_3 to 25-Hydroxyvitamin D_3 and 1α, 25-Dihydroxyvitamin D_3

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概要

• 論文の詳細を見る

• Amycolata autorophica converts vitamin D_3(VD_3) to 1α, 25-dihydroxyvitamin D_3(1α, 25(OH)_2VD_3) via 25-hydroxyvitamin D_3(25(OH)VD_3) by hydroxylation of VD_3 at C-25 and C-1. In this microbial hydroxylation, it was found that cyclodextrin (CD) had the ability to enhance the hydroxylation of VD_3. Addition of partially-methylated-β-cyclodextrin (PMCD) increased the productivity of 25(OH)VD_3 about seven-fold compared to that without CD. Combined use of PMCD and γ-CD increased the production of 1α, 25(OH)_2VD_3 in a tank fermentor about sixteen-fold compared to that without CD.

• 社団法人日本生物工学会の論文
• 1994-11-25

著者

• OKAMOTO ROKURO

  Central Research Laboratories, Sanraku-Ocean Co., Ltd.,

• Kubo Kanako

  Department Of Applied Chemistry And Chemical Engineering Faculty Of Engineering Yamaguchi University

• Omura Sadafumi

  Research Center, Taisho Pharmaceutical Co., LTD.

• OKAMURA Kazuhiko

  Central Research Laboratories, Mercian Corporation

• Okamura K

  Advanced Technology Research Department Institute Of Technology Shimizu Corporation

• Okamura K

  Mercian Corporation Central Research Laboratories

• Omura S

  Taisho Pharmaceutical Co. Ltd. Saitama Jpn

• Omura Sadafumi

  Research Center Taisho Pharmaceutical Co. Ltd.

• Okamoto R

  Mercian Corp. Fujisawa Jpn

• Sasaki J

  Medicinal Research Laboratories And Pharmaceutical Research Laboratories Taisho Pharmaceutical Co. L

• Sasaki Joji

  Research Center Taisho Pharmaceutical Co. Ltd.

• Kubo K

  Department Of Applied Chemistry And Chemical Engineering Faculty Of Engineering Yamaguchi University

• Okamura K

  Mercian Corp. Kanagawa Jpn

• Okamura Kazuhiko

  Central Research Laboratories Sanraku Incorporated

• Okamura Kazuhiko

  Central Research Laboratories Mercian Corporation

• TAKEDA KOJI

  Central Research Laboratories, Mercian Corp.,

• ASOU TORU

  Central Research Laboratories, Mercian Corp.,

• MATSUDA ATUSHI

  Central Research Laboratories, Mercian Corp.,

• KIMURA KIYOSHI

  Central Research Laboratories, Mercian Corp.,

• ADACHI TAKASHI

  Research Center, Taisho Pharmaceutical Co. Ltd.,

• Okamoto Rokuro

  Central Research Laboratories Mercian Corporation

• Takeda Koji

  Central Research Laboratories Mercian Corp. :(present Adress)process Research Center Mercian Corp.

• Asou T

  Central Research Laboratories Mercian Corp.

• Matsuda A

  Mercian Corp. Kanagawa Jpn

• Okamura Kazuhiko

  Central Research Laboratories Mercian Co. Ltd.

• Adachi Takashi

  Research Center Taisho Pharmaceutical Co. Ltd.

• Okamura Kazuhiko

  Central Research Laboratories Marcian Corp.

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