The Homeostasis Model Assessment-insulin Resistance Index Is Inversely Associated with Serum Carotenoids in Non-diabetic Subjects

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概要

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• BACKGROUND: Carotenoids may reduce the risk for diabetes mellitus, but little is known about the association of insulin resistance with serum carotenoids in non-diabetic subjects. This study aimed to investigate whether the homeostasis model assessment-insulin resistance (HOMA-IR) index would be lower in the presence of high serum carotenoid concentrations in non-diabetic subjects.METHODS: A total of 812 subjects (256 males and 556 females) who had received health examinations in 2003 participated in the study. The associations of the serum-carotenoid concentrations and HOMA-IR were evaluated cross-sectionally. The multivariate-adjusted geometric means of HOMA-IR by the tertiles of the serum carotenoid concentration were calculated after adjusting for age, body mass index, systolic blood pressure, total cholesterol, triacylglycerols, current tobacco use, regular alcohol intake, exercise habits and total energy intake. Associations among high HOMA-IR (3.0+ mU×mmol/L2) across tertiles of serum carotenoid concentration were assessed by tests for logistic regression analysis.RESULTS: In male subjects, the multivariate adjusted geometric mean of HOMA-IR was inversely associated with the serum β-cryptoxanthin concentrations. In female subjects, an inverse association of the serum carotenoid concentration and HOMA-IR was observed in lycopene, β-cryptoxanthin, and zeaxanthin. The confounding factor-adjusted odds ratios (OR) for high HOMA-IR on the highest tertiles of serum α-carotene, β-carotene, β-cryptoxanthin, and zeaxanthin were 0.18 [95% confidence interval (CI): 0.06-0.52], 0.22 (95% CI: 0.07-0.67), 0.34 (95% CI: 0.12-0.96), and 0.30 (95% CI: 0.11-0.79), respectively, in male subjects. On the other hand, in female subjects, the adjusted OR for high HOMA-IR on the highest tertiles of serum lycopene and β-cryptoxanthin were 0.39 (95% CI: 0.21-0.73) and 0.51 (95% CI: 0.28-0.95), respectively.CONCLUSIONS: The serum antioxidant carotenoids were inversely associated with HOMA-estimated insulin resistance in non-diabetic subjects.J Epidemiol 2006; 16: 71-78.

• 日本疫学会の論文
• 2006-03-01

著者

• KATO Masaya

  Department of Physics,Division of Material Science,Nagoya University

• Ikoma Yoshinori

  農業・生物系特定産業技術研究機構果樹研究所

• Kato Masaya

  Department Of Cardiology Hiroshima City Asa Hospital

• Matsumoto Hikaru

  農業･生物系特定産業技術研究機構果樹研究所

• Matsumoto Hikaru

  Department Of Citrus Research National Institute Of Fruit Tree Science

• Yano Masamichi

  Department of Cardiology, Knasai Rosai Hospital

• Sugiura Minoru

  Department of Citrus Research, National Institute of Fruit Tree Science.

• Nakamura Mieko

  Department of Epidemiology, National Institute for Longevity Sciences.

• Ogawa Kazunori

  Department of Citrus Research, National Institute of Fruit Tree Science.

• Ohshima Makoto

  Department of Citrus Research, National Institute of Fruit Tree Science.

• Nagao Akihiko

  Food Materials Research Division, National Food Research Institute.

• Yano Masamichi

  Department Of Citrus Research National Institute Of Fruit Tree Science

• Matsumoto Hikaru

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut

• Ikoma Yoshinori

  Department Of Citriculture National Institute Of Fruit Tree Science

• Ogawa K

  Department Of Citrus Research National Institute Of Fruit Tree Science

• Ogawa Kazunori

  Department Of Child Neurology Okayama University Graduate School Of Medicine And Dentistry

• Nakamura Mieko

  Dep. Of Community Health And Preventive Medicine Hamamatsu Univ. School Of Medicine

• Nakamura Mieko

  Department Of Community Health And Preventive Medicine Hamamatsu University School Of Medicine

• Ohshima Makoto

  Department Of Citrus Research National Institute Of Fruit Tree Science

• Ohshima Makoto

  Department Of Applied Physics Tohoku University

• Sugiura Minoru

  Department Of Citrus Research National Institute Of Fruit Tree Science

• Sugiura Minoru

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• Yano M

  Department Of Citrus Research National Institute Of Fruit Tree Science

• Yano Masamichi

  Department Of Citriculture National Institute Of Fruit Tree Science

• Yano Masamichi

  Dept. Citriculture Natl. Inst. Fruit Tree Sci.

• Ogawa Kazunori

  Department Of Citrus Research National Institute Of Fruit Tree Science

• Nagao A

  National Food Res.inst. Ibaraki Jpn

• Nagao Akihiko

  Food Materials Research Division National Food Research Institute

• Okamura K

  Mercian Corporation Central Research Laboratories

• OGAWA Kazunori

  Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo

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