Design of Double-Drug-Type Anti-HIV Agents
スポンサーリンク
概要
- 論文の詳細を見る
- 2001-03-01
著者
-
Matsumoto H
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut
-
Matsumoto Hikaru
Department Of Citrus Research National Institute Of Fruit Tree Science
-
Sano Kouichi
Department of Cardiology, Saitama International Medicin Center
-
Matsumoto Hikaru
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut
-
KIMURA Tooru
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Centur
-
HAYASHI Yoshio
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Centur
-
KISO Yoshiaki
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Centur
-
HAMAWAKI Tomonori
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
-
OTA Hisashi
Department of Medical Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmaceut
-
GOTO Toshiyuki
Department of Microbiology, Osaka Medical College
-
Sano Kouichi
Department Of Microbiology Osaka Medical College
-
Kimura T
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
-
Ota Hisashi
Department Of Medical Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceutic
-
Kiso Yoshiaki
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
-
Hayashi Yoshio
Department Of Electrical And Electronic Engineering Kitami Institute Of Technology
-
Hamawaki Tomonori
Department Of Medical Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceutic
-
Kimura Tooru
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut
-
Sano Kouichi
Department Of Cardiology Saitama International Medicin Center
-
Kimura T
Peptide Inst. Inc. Minoh Jpn
-
Hayashi Yoshio
Department Of Chemistry Faculty Of Science Kanazawa University
-
Goto Toshiyuki
Department Of Microbiology Osaka Medical College
-
KISO Yoshiaki
Department of Ecological Engineering, Toyohashi University of Technology, JAPAN.
関連論文
- Effect of 1-methylcyclopropene on the expression of genes for ascorbate metabolism in postharvest broccoli
- High Serum Carotenoids Are Inversely Associated with Serum Gamma-glutamyltransferase in Alcohol Drinkers within Normal Liver Function
- PE-462 Initial Experience of SPECT-CT in Our hospital : Comparison with Conventional SPECT(Nuclear cardiology(05)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Development of New Photoresponsive Paclitaxel Prodrug
- Phototaxel : Development of First Photoresponsive Prodrug of Paclitaxel via Modification of Phenylisoserine Moiety
- "Click Peptide" : the "O-Acyl Isopeptide Method" for Peptide Synthesis and Development of Chemical Biology-Oriented Aβ Analogues
- "Click Peptide" Based on the "O-Acyl Isopeptide Method" : Development of Chemical Biology-Oriented Alzheimer's Disease-Related Aβ1-42 Analogues
- Design and Synthesis of Dipeptide-type HIV-1 Protease Inhibitors with High Antiviral Activity
- Controlled Drug Release : Design and Application of New Water-soluble Prodrugs
- Spontaneously Regenerable Prodrug : Design and Synthesis of Water-soluble Prodrugs of HIV Protease Inhibitors
- Design of Double-Drug-Type Anti-HIV Agents
- New Type Prodrugs of Anti-HIV Agents Consisting of the HIV Protease Inhibitor and Reverse Transcriptase Inhibitor
- Synthesis and Activity of a New Type of Anti-HIV Agents, Conjugate of HIV Protease Inhibitor with Reverse Transcriptase Inhibitor
- Synthesis of an HIV-1 Protease Analogue by the Chemoselective Ligation Method Using a New Disulfide Type Linker
- Racemization-Free Segment Condensation Based on Isopeptide Method : An Efficient Preparation of Peptides on Solid Support
- The Synthesis of Bioactive Peptides Based on O-Acyl Isopeptide Method : Application of O-Acyl Isodipeptide Units
- Development of Racemization-Free "O-Acyl Isopeptide Method" Utilizing the "O-Acyl Isodipeptide Unit"
- P-262 "O-ACYL ISOPEPTIDE METHOD" FOR THE EFFICIENT SYNTHESIS OF DIFFICULT SEQUENSE-CONTAINING PEPTIDES : UTILIZATION OF "O-ACYL ISODIPEPTIDE UNIT"
- Conversion of Polymer-Bound Dipeptide to Evans-Type Chiral Auxiliary : A New Tool for Efficient Solid-Phase Asymmetric Reactions
- An improved procedure of electron microscopic in situ hybridization for detecting adenovirus DNA
- Revised Japanese criteria for Sjogren's syndrome (1999) : availability and validity
- FEM-Based Electromagnetic Wave Simulator Running on Some Platforms by Use of Java and a Commercial Tool(Analytical and Simulation Methods for Electromagnetic Wave Problems)
- FEM-Based Electromagnetic Wave Simulator Running on Some Platforms by Use of Java and a Commercial Tool
- Development of Spontaneously Regenerable Water-Soluble Prodrugs Based on the Peptide Chemistry : Importance of Drug Release Time for the Improvement of Gastrointestinal Absorption
- Structure-Activity Relationship of Orally Potent Tripeptide-Based HIV Protease Inhibitors Containing Hydroxymethylcarbonyl Isostere
- Small-sized HIV Protease Inhibitors Containing Allophenylnorstatine as a Substrate Transition-state Mimic
- Design of HIV Protease Inhibitors Based on the Transition State Analogue Concept
- Metastatic Prostate Carcinoma to the Mandible : Report of a case
- Malignant Melanoma in situ of the Lower Lip
- Accumulation of Carotenoids and Expression of Carotenoid Biosynthetic Genes and Carotenoid Cleavage Dioxygenase Genes during Fruit Maturation in the Juice Sacs of 'Tamami,' 'Kiyomi' Tangor, and 'Wilking' Mandarin
- The Homeostasis Model Assessment-insulin Resistance Index Is Inversely Associated with Serum Carotenoids in Non-diabetic Subjects
- Quantitation of Carotenoids in Raw and Processed Fruits in Japan
- Seasonal Changes in the Relationship between Serum Concentration of β-Cryptoxanthin and Serum Lipid Levels
- Multiple Linear Regression Analysis of the Seasonal Changes in the Serum Concentration of β-Cryptoxanthin
- Differential Susceptibility of Cells Expressing Allogeneic MHC or Viral Antigen to Killing by Antigen-Specific CTL
- Novel BACE1 Inhibitors : Design Approach Focused on Inhibitor's Conformer
- Structure-Activity Relationship Study of BACE1 Inhibitors Containing Chelidonamide
- Synthesis of HIV Protease Dipeptide Inhibitors and Prodrugs
- Oligoarginine-Based Prodrugs with Self-Cleavable Spacers for Caco-2 Cell Permeation
- Synthesis and Activity of Tetrapeptidic Human T-cell Leukemia Virus Type I Protease Inhibitors Possessing Different P_1'- and P_3-cap Moieties
- Design of BACE1 Inhibitors : Replacing the P_1' Residue with Non-Acidic Moiety
- Design and Synthesis of Conformationally Constrained Dimerization Inhibitors of HIV-1 Protease
- Serum Concentration of β-Cryptoxanthin in Japan Reflects the Frequency of Satsuma Mandarin (Citrus unshiu Marc.) Consumption
- Synthesis of Negamycin and Its Derivatives as Potential Therapeutic Agents for Duchenne Muscular Dystrophy
- Phenylthionorstatine as a Transition-State Mimic in BACE1 Inhibitors
- Tripeptide Mimetics with Potent Inhibitory Activity against Malarial Aspartic Protease Plasmepsin II
- P-296 DEVELOPMENT OF RESIN SUPPORTED EVANS-TYPE CHIRAL AUXILIARY FOR SOLID-PHASE ASYMMETRIC REACTION
- Modification of P4 Position in β-secretase (BACE1) Inhibitors Containing Phenylnorstatine
- Design of β-Secretase (BACE1) Inhibitors with Carboxylic Acid Bioisosteres
- Convenient and Regioselective Syntheses of 3, 4-Disubsutituted Δ^3-Pyrrolin-2-one Derivatives Starting from 2-Tosyl-3, 4-Disubstituted Pyrroles
- Nanotransportation system for cholera toxin in Vibrio cholerae 01
- Evaluation of Peptidomimetic HTLV-I Protease Inhibitors Containing Hydroxymethylcarbonyl as a Transition-State Isostere
- O-N Intramolecular Acyloxy Migration Reaction : from the Prodrug Strategy to the Migration of Protective Groups in Amino Acids
- "Click Peptide" Based on the "O-Acyl Isopeptide Method" : an Efficient Preparation of Amyloid β Peptide 1-42 Mutants
- Design and Synthesis of β-Secretase Inhibitors Containing Hydroxymethylcarbonyl Isostere as a Transition State Mimic
- SYNTHESES AND STRUCTURE-ACTIVITY RELATIONSHIPS OF ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES
- A Novel S-Acyl Isopeptide Method for the Synthesis of Difficult Sequence-Containing Peptide
- Isopeptide Method : A Racemization-Free Peptide Synthesis by Segment Condensation
- Three-dimensional Quantitative Structure-Activity Relationship Analysis of RGD Mimetics as Fibrinogen Receptor Antagonists
- Synthesis and Biological Activities of Phenylahistin Derivatives
- Design and Synthesis of Inhibitory Peptides against EGF Receptor Dimerization
- SAR study of BACE1 inhibitors containing pyridine derivatives
- Significance of interaction of BACE1-Arg235 with its ligands and design of BACE1 inhibitors
- Chemical Synthesis of 71-meric Neuregulin 1-β1
- The Rate of Cell Growth Is Regulated by Purine Biosynthesis via ATP Production and G1 to S Phase Transition
- Mechanisms of Transfer into SCID Mice Reconstituted with Tissueinfiltrating Cells from Murine Model for Sjogren's Syndrome
- Large Cell Undifferentiated Carcinoma of the Parotid Gland Containing Malignant Oncocytic Change
- Click Peptide by Use of the O-Acyl Isopeptide Method : Production of Amyloid β Peptide from Water-Soluble Analogue
- "O-Acyl Isopeptide Method" for the Synthesis of Difficult Sequence-Containing Peptides : Application to the Synthesis of Amyloid β Peptide (Aβ) 1-42
- Effect of the Phenyl Ring Modification on the Antitumor Activity of Anti-Microtubule Agent Dehydrophenylahistin
- Uptake Mechanisms of FITC-Oligoarginine Conjugates in HeLa Cells
- Design and Synthesis of Oligoarginine-Fluorescein Conjugates Possessing Novel Self-Cleavable Spacers as a Model for Effective Intestinal Absorption
- Cross-Sectional Analysis of Satsuma mandarin (Citrus unshiu Marc.) Consumption and Health Status Based on a Self-Administered Questionnaires
- Efficient Total Synthesis of (+)-Negamycin and Its Derivatives
- Small Peptide-based Medicinal Chemistry for Intractable Disease
- A Synthetic Method for Monodehydro-Cyclic-Dipeptides toward Natural Product Synthesis
- New Aspects of Potent Anti-Microtubule Agents Phenylahistin and Tubulin Photoaffinity Labeling
- P-518 DEVELOPMENT OF POTENT ANTI-MICROTUBULE AGENTS BASED ON NATURAL DIKETOPIPERAZINE PHENYLAHISTIN AND TUBULIN PHOTOAFFINITY LABELING
- Development of a New Synthetic Method for Monodehydro-2,5-diketopiperazines
- Synthetic Study of Anti-microtubule Diketopiperazines : Phenylahistin and Aurantiamine
- Studies on N^〈in〉-Protecting Groups during the Synthesis of Trp : Containing Cystine Peptide by Silyl Chloride Sulfoxide Method
- A Reductive Acidolysis Final Deprotection Strategy in Solid Phase Peptide Synthesis Based on Safety-Catch Protection
- Effect of Dipeptidomimetics on Malaria Parasite Proliferation Inhibition Targeting Plasmepsin
- Design and Synthesis of Highly Active β-Secretase (BACE1) inhibitors, KMI-420 and KMI-429, with Enhanced Chemical Stability
- Evaluation of Peptidomimetic Inhibitors against Malarial Protease Plasmepsin
- Dipeptide-Type Inhibitors Targeting Plasmepsins from Plasmodium Falciparum
- Analysis of Side Reaction in the Amide Bond Formation with an α-Hydroxy-β-amino Acid as an Acyl Componemt
- Substrate Transition-State Analogue Inhibitors of Plasmepsin II as Antimalarial Drugs
- An Approach for Peptidic Aspartic Protease Inhibitors Using Ala-containing Oligopeptides Independent of the Substrate Sequence
- Development of a New Synthetic Method for L-Tetrahydrofuranylglycine and Its Application for Substrate-based HIV-1 Protease Inhibitors
- Synthesis of Human C-Type Natriuretic Peptide 22 Using Chlorotrityl Resin and Tetrafluoroboric Acid Deprotection
- Carcinoma in Pleomorphic Adenoma of the Tongue : Report of a case
- SYNTHESES AND STRUCTURE-ACTIVITIES RELATIONSHIPS OF SMALLSIZED ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES WITH POTENT ACTIVITY
- Solid Phase Synthesis of a Mercaptoamide Peptide Using New Linkers
- SYNTHESES OF CYSTINE-PEPTIDES BY A NEW DISULPHIDE BOND FORMING REACTION
- Delivery of small interfering RNA with a synthetic collagen poly (Pro-Hyp-Gly) for gene silencing in vitro and in vivo
- Epitope mapping of anti-α-fodrin antibody in a case of early-onset multiple sclerosis
- Effect of 1-methylcyclopropene on the expression of genes for ascorbate metabolism in postharvest cauliflower
- Effect of electrostatic atomization on ascorbate metabolism in postharvest broccoli
- Expression and functional analysis of two lycopene β-cyclases from citrus fruits