High Serum Carotenoids Are Inversely Associated with Serum Gamma-glutamyltransferase in Alcohol Drinkers within Normal Liver Function
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概要
- 論文の詳細を見る
BACKGROUND: Many studies have reported that the consumption of alcohol induces the generation of free radicals. Moreover, recent studies suggest that serum gamma-glutamyltransferase (γ-GTP) within its normal range might be an early marker of oxidative stress. In this study, we tested the hypothesis that serum antioxidant carotenoids would be inversely associated with serum γ-GTP in alcohol drinkers within normal liver function.METHODS: A total of 266 Japanese men who had received health examination in 2003 participated in the study. The associations of serum γ-GTP and serum-carotenoid concentrations stratified by alcohol intake levels were evaluated cross-sectionally. The participants were divided into three groups according to their ethanol intake level (non-drinker, less than 1 g/day; light drinker, 1-25 g/day; and moderate and heavy drinkers, 25+ g/day). The multivariate-adjusted geometric means of the serum γ-GTP concentrations in each tertile of the serum-carotenoid concentrations were calculated after adjustment for ethanol intake, age, body mass index, total cholesterol, triacylglycerols, current tobacco use, and habitual exercise.RESULTS: The serum γ-GTP concentrations were significantly high in accordance with the ethanol intake level. In moderate and heavy drinkers, the multivariate-adjusted geometric means of serum γ-GTP concentrations were significantly low in accordance with the tertiles of the serum lycopene, α-carotene, β-carotene, and β-cryptoxanthin concentrations.CONCLUSIONS: The serum antioxidant carotenoids were inversely associated with alcohol-induced increases of serum γ-GTP in moderate and heavy drinkers within normal liver function.J Epidemiol 2005; 15: 180-186.
- 日本疫学会の論文
著者
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KATO Masaya
Department of Physics,Division of Material Science,Nagoya University
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Ikoma Yoshinori
農業・生物系特定産業技術研究機構果樹研究所
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Kato Masaya
Department Of Cardiology Hiroshima City Asa Hospital
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Matsumoto Hikaru
Department Of Medicinal Chemistry Center For Frontier Research Medicinal Science Kyoto Pharmaceutica
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Matsumoto Hikaru
Department Of Citrus Research National Institute Of Fruit Tree Science
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Yano Masamichi
Department of Cardiology, Knasai Rosai Hospital
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Sugiura Minoru
Department of Citrus Research, National Institute of Fruit Tree Science.
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Nakamura Mieko
Department of Epidemiology, National Institute for Longevity Sciences.
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Ikoma Yoshinori
Department of Citrus Research, National Institute of Fruit Tree Science.
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Ogawa Kazunori
Department of Citrus Research, National Institute of Fruit Tree Science.
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Ohshima Makoto
Department of Citrus Research, National Institute of Fruit Tree Science.
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Nagao Akihiko
Food Materials Research Division, National Food Research Institute.
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Ikoma Yoshinori
Department Of Citriculture National Institute Of Fruit Tree Science
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Nakamura Mieko
Department Of Community Health And Preventive Medicine Hamamatsu University School Of Medicine
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Ohshima Makoto
Department Of Applied Physics Tohoku University
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Sugiura Minoru
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Nagao Akihiko
Food Materials Research Division National Food Research Institute
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OGAWA Kazunori
Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo
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Yano Masamichi
Department of Citrus Research, National Institute of Fruit Tree Science.
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Matsumoto Hikaru
Department of Citrus Research, National Institute of Fruit Tree Science.
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