High Serum Carotenoids Are Inversely Associated with Serum Gamma-glutamyltransferase in Alcohol Drinkers within Normal Liver Function

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概要

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• BACKGROUND: Many studies have reported that the consumption of alcohol induces the generation of free radicals. Moreover, recent studies suggest that serum gamma-glutamyltransferase (γ-GTP) within its normal range might be an early marker of oxidative stress. In this study, we tested the hypothesis that serum antioxidant carotenoids would be inversely associated with serum γ-GTP in alcohol drinkers within normal liver function.METHODS: A total of 266 Japanese men who had received health examination in 2003 participated in the study. The associations of serum γ-GTP and serum-carotenoid concentrations stratified by alcohol intake levels were evaluated cross-sectionally. The participants were divided into three groups according to their ethanol intake level (non-drinker, less than 1 g/day; light drinker, 1-25 g/day; and moderate and heavy drinkers, 25+ g/day). The multivariate-adjusted geometric means of the serum γ-GTP concentrations in each tertile of the serum-carotenoid concentrations were calculated after adjustment for ethanol intake, age, body mass index, total cholesterol, triacylglycerols, current tobacco use, and habitual exercise.RESULTS: The serum γ-GTP concentrations were significantly high in accordance with the ethanol intake level. In moderate and heavy drinkers, the multivariate-adjusted geometric means of serum γ-GTP concentrations were significantly low in accordance with the tertiles of the serum lycopene, α-carotene, β-carotene, and β-cryptoxanthin concentrations.CONCLUSIONS: The serum antioxidant carotenoids were inversely associated with alcohol-induced increases of serum γ-GTP in moderate and heavy drinkers within normal liver function.J Epidemiol 2005; 15: 180-186.

• 日本疫学会の論文

著者

• KATO Masaya

  Department of Physics,Division of Material Science,Nagoya University

• Ikoma Yoshinori

  農業・生物系特定産業技術研究機構果樹研究所

• Kato Masaya

  Department Of Cardiology Hiroshima City Asa Hospital

• Matsumoto Hikaru

  Department Of Medicinal Chemistry Center For Frontier Research Medicinal Science Kyoto Pharmaceutica

• Matsumoto Hikaru

  Department Of Citrus Research National Institute Of Fruit Tree Science

• Yano Masamichi

  Department of Cardiology, Knasai Rosai Hospital

• Sugiura Minoru

  Department of Citrus Research, National Institute of Fruit Tree Science.

• Nakamura Mieko

  Department of Epidemiology, National Institute for Longevity Sciences.

• Ikoma Yoshinori

  Department of Citrus Research, National Institute of Fruit Tree Science.

• Ogawa Kazunori

  Department of Citrus Research, National Institute of Fruit Tree Science.

• Ohshima Makoto

  Department of Citrus Research, National Institute of Fruit Tree Science.

• Nagao Akihiko

  Food Materials Research Division, National Food Research Institute.

• Ikoma Yoshinori

  Department Of Citriculture National Institute Of Fruit Tree Science

• Nakamura Mieko

  Department Of Community Health And Preventive Medicine Hamamatsu University School Of Medicine

• Ohshima Makoto

  Department Of Applied Physics Tohoku University

• Sugiura Minoru

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• Nagao Akihiko

  Food Materials Research Division National Food Research Institute

• OGAWA Kazunori

  Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo

• Yano Masamichi

  Department of Citrus Research, National Institute of Fruit Tree Science.

• Matsumoto Hikaru

  Department of Citrus Research, National Institute of Fruit Tree Science.

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