A Reductive Acidolysis Final Deprotection Strategy in Solid Phase Peptide Synthesis Based on Safety-Catch Protection

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概要

• 論文の詳細を見る

• A reductive acidolysis final deprotection strategy in solid phase peptide synthesis was developed using a new safety-catch type of semi-permanent protecting groups and new linkers which were derived from 4-methylsulfinylbenzyl protection. This new strategy was based on a two-dimensional protection scheme employing acid-labile temporary and acid-stable but reductive acidolysis-cleavable semi-permanent protecting groups. By using this strategy, we successfully synthesized four model peptides, of which two contained C-terminal amide.

• 公益社団法人日本薬学会の論文
• 1997-01-15

著者

• Akaji Kenichi

  Department of Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicin

• Kiso Y

  Department Of Medicinal Chemistry Kyoto Pharmaceutical University

• KIMURA Tooru

  Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Centur

• KISO Yoshiaki

  Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Centur

• Akaji K

  Kyoto Pharmaceutical Univ. Kyoto Jpn

• Akaji Kenichi

  Department Of Medicinal Chemistry Kyoto Pharmaceutical University

• Tanaka Shigeki

  Department Of Surgery Yokohama City University Hospital And School Of Medicine

• Kimura T

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• Fukui T

  Department Of Medicinal Chemistry Kyoto Pharmaceutical University

• Fukui Toshio

  Department Of Medicine School Of Medicine Keio University And Department Medicine Kawasaki Municipal

• Kiso Yoshiaki

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• Tanaka S

  Department Of Medicinal Chemistry Kyoto Pharmaceutical University

• Akaji Kenichi

  Department Of Chemistry Graduate School Of Medical Science Kyoto Prefectural University Of Medicine

• Kimura Tooru

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut

• Tanaka Shigeki

  Department Of Applied Chemistry Tokai University

• Akaji Kenichi

  Department Of Medicinal Chemistry Graduate School Of Medical Science Kyoto Prefectural University Of

• Kimura T

  Peptide Inst. Inc. Minoh Jpn

• Fukui Toshio

  Department of Medicinal Chemistry, Kyoto Pharmaceutical University

• KISO Yoshiaki

  Department of Ecological Engineering, Toyohashi University of Technology, JAPAN.

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