Structural Analysis of Amyloid-β Protein Fibrils Formed in Raft-Like Model Membranes

スポンサーリンク

概要

• 論文の詳細を見る
• 2007-03-01

著者

• Naiki Hironobu

  Faculty of Medical Sciences, Univ of Fukui

• Kiso Y

  Department Of Medicinal Chemistry Kyoto Pharmaceutical University

• MATSUZAKI Katsumi

  Graduate School of Pharmaceutical Sciences, Kyoto University

• IKEDA Keisuke

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Yano Yoshiaki

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Naiki Hironobu

  Fac. Med. Sci. Univ Of Fukui

• Naiki H

  Fukui Medical Univ. Fukui

• Naiki Hironobu

  Second Department Of Pathology University Of Fukui

• Naiki Hironobu

  Faculty Of Medical Sciences University Of Fukui

• Kinoshita Yuko

  Department Of Oriental Medicine Nihon University School Of Medicine

• Ikeda Keisuke

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Hasegawa Kazuhiro

  Fac. Med. Sci. Fukui Univ.

• Hoshino M

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Hoshino Masaru

  Graduate School Of Pharmaceutical Sciences Kyoto University

• KISO Yoshiaki

  Kyoto Pharmaceutical University

• HASEGAWA Kazuhiro

  Faculty of Medical Sciences, University of Fukui

• SOHMA Youhei

  Kyoto Pharmaceutical University

• HAYASHI Yoshio

  Kyoto Pharmaceutical University

• Hasegawa Kazuhiro

  Faculty Of Medical Sciences University Of Fukui

• Sohma Youhei

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• Ikeda Keisuke

  Institute For Protein Research Osaka University

• Yano Yoshiaki

  Graduate School Of Biostudies Kyoto University

• Kiso Yoshiaki

  Kyoto Pharmaceutical Univ. Kyoto Jpn

• Matsuzaki Katsumi

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Matsuzaki Katsumi

  Graduate School Of Biostudies Kyoto University

• Hoshino M

  Institute For Protein Research Osaka University And Crest Japan Science And Technology Cooperation

• Kiso Yoshiaki

  Protein Research Group Riken Genomic Sciences Center

• Yano Yoshiaki

  Kyoto Univ. Kyoto Jpn

• Yamaguchi H

  Department Of Oral Molecular Pathology Institute Of Health Bioscience The University Of Tokushima Gr

• Hayashi Yoshio

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut

• Ikeda Keisuke

  Graduate School Of Agriculture Hokkaido University

関連論文

• 2P-083 Trp蛍光とH/D交換-NMR法をもちいたβ_2ミクログロブリンのアミロイド線維形成反応中間体の解析(蛋白質・物性(2),第46回日本生物物理学会年会)
• Development of New Photoresponsive Paclitaxel Prodrug
• Phototaxel : Development of First Photoresponsive Prodrug of Paclitaxel via Modification of Phenylisoserine Moiety
• "Click Peptide" : the "O-Acyl Isopeptide Method" for Peptide Synthesis and Development of Chemical Biology-Oriented Aβ Analogues
• "Click Peptide" Based on the "O-Acyl Isopeptide Method" : Development of Chemical Biology-Oriented Alzheimer's Disease-Related Aβ1-42 Analogues
• 2P122 新規コイルドコイルラベル法を用いた生細胞膜での受容体オリゴマー化解析法の開発(膜蛋白質,第48回日本生物物理学会年会)
• New Type Prodrugs of Anti-HIV Agents Consisting of the HIV Protease Inhibitor and Reverse Transcriptase Inhibitor
• Synthesis and Activity of a New Type of Anti-HIV Agents, Conjugate of HIV Protease Inhibitor with Reverse Transcriptase Inhibitor
• Synthesis of an HIV-1 Protease Analogue by the Chemoselective Ligation Method Using a New Disulfide Type Linker
• Racemization-Free Segment Condensation Based on Isopeptide Method : An Efficient Preparation of Peptides on Solid Support
• The Synthesis of Bioactive Peptides Based on O-Acyl Isopeptide Method : Application of O-Acyl Isodipeptide Units
• Development of Racemization-Free "O-Acyl Isopeptide Method" Utilizing the "O-Acyl Isodipeptide Unit"
• P-262 "O-ACYL ISOPEPTIDE METHOD" FOR THE EFFICIENT SYNTHESIS OF DIFFICULT SEQUENSE-CONTAINING PEPTIDES : UTILIZATION OF "O-ACYL ISODIPEPTIDE UNIT"
• 1P120 1I1240 1分子蛍光計測による膜貫通ヘリックス間相互作用揺らぎの検出(膜蛋白質,口頭発表,第48回日本生物物理学会年会)
• 2P105 Structural polymorphism of β_2-microglobulin amyloid fibrils induced by the addition of trifluoroethanol(31. Protein folding and misfolding (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
• 1P064 常磁性緩和促進を用いたβ2ミクログロブリンの中間状態構の解析(蛋白質-物性(安定性,折れたたみなど),第48回日本生物物理学会年会)
• Properties of Intracellular Fragment Peptides of Mouse Prostaglandin E_2 Receptor EP3 Isoform
• Structure-Activity Relationship of Orally Potent Tripeptide-Based HIV Protease Inhibitors Containing Hydroxymethylcarbonyl Isostere
• Small-sized HIV Protease Inhibitors Containing Allophenylnorstatine as a Substrate Transition-state Mimic
• Design of HIV Protease Inhibitors Based on the Transition State Analogue Concept
• Elucidation of Membrane Protein Folding Using Model Transmembrane Helices
• Thermodynamics of Hydrophobic Mismatch for Transmembrane Helix-Helix and Helix-Lipid Interactions
• Novel BACE1 Inhibitors : Design Approach Focused on Inhibitor's Conformer
• Structure-Activity Relationship Study of BACE1 Inhibitors Containing Chelidonamide
• Synthesis of HIV Protease Dipeptide Inhibitors and Prodrugs
• Oligoarginine-Based Prodrugs with Self-Cleavable Spacers for Caco-2 Cell Permeation
• Synthesis and Activity of Tetrapeptidic Human T-cell Leukemia Virus Type I Protease Inhibitors Possessing Different P_1'- and P_3-cap Moieties
• Design of BACE1 Inhibitors : Replacing the P_1' Residue with Non-Acidic Moiety
• Design and Synthesis of Conformationally Constrained Dimerization Inhibitors of HIV-1 Protease
• Synthesis of Negamycin and Its Derivatives as Potential Therapeutic Agents for Duchenne Muscular Dystrophy
• Structural Analysis of Amyloid-β Protein Fibrils Formed in Raft-Like Model Membranes
• Inhibition of Amyloid β-Protein Aβ-(1-42) Induced Cytotoxicity by Helical Aβ Analog
• Phenylthionorstatine as a Transition-State Mimic in BACE1 Inhibitors
• Tripeptide Mimetics with Potent Inhibitory Activity against Malarial Aspartic Protease Plasmepsin II
• P-296 DEVELOPMENT OF RESIN SUPPORTED EVANS-TYPE CHIRAL AUXILIARY FOR SOLID-PHASE ASYMMETRIC REACTION
• Modification of P4 Position in β-secretase (BACE1) Inhibitors Containing Phenylnorstatine
• Design of β-Secretase (BACE1) Inhibitors with Carboxylic Acid Bioisosteres
• 2P051 超音波による高速アミロイド線維形成反応(蛋白質-物性(安定性,折れたたみなど),第48回日本生物物理学会年会)
• 2P-052 SDSL-ESRを用いたアミロイド線維構造に関する研究(蛋白質-物性(安定性,折れたたみなど),第47回日本生物物理学会年会)
• 2P-048 重水素交換法を用いたアミロイド線維伸長機構の解析(蛋白質-物性(安定性,折れたたみなど),第47回日本生物物理学会年会)
• 2P-051 GM1ガングリオシドクラスターを介したアミロイドβタンパク質の凝集機構(蛋白質-物性(安定性,折れたたみなど),第47回日本生物物理学会年会)
• Specific Fluorescence Labeling of Membrane Receptors in Living Cells using Coiled-coil Tag
• Effects of Peptide Dimerization on Pore Formation : Antiparallel Disulfide-Dimerized Magainin 2 Analog
• SYNTHESES AND STRUCTURE-ACTIVITY RELATIONSHIPS OF ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES
• High-throughput Screening Method for Ligand Peptides Using Capillary Electrophoresis-Mass Spectrometry (CE-MS)
• A Novel S-Acyl Isopeptide Method for the Synthesis of Difficult Sequence-Containing Peptide
• Isopeptide Method : A Racemization-Free Peptide Synthesis by Segment Condensation
• Design and Synthesis of Inhibitory Peptides against EGF Receptor Dimerization
• SAR study of BACE1 inhibitors containing pyridine derivatives
• Significance of interaction of BACE1-Arg235 with its ligands and design of BACE1 inhibitors
• Chemical Synthesis of 71-meric Neuregulin 1-β1
• Click Peptide by Use of the O-Acyl Isopeptide Method : Production of Amyloid β Peptide from Water-Soluble Analogue
• Development of Biotin-Tagged Tubulin Photoaffinity Probes Derivatized from Diketopiperazine Based Anti-Microtubule Agents
• Effect of the Phenyl Ring Modification on the Antitumor Activity of Anti-Microtubule Agent Dehydrophenylahistin
• Uptake Mechanisms of FITC-Oligoarginine Conjugates in HeLa Cells
• Efficient Total Synthesis of (+)-Negamycin and Its Derivatives
• Small Peptide-based Medicinal Chemistry for Intractable Disease
• A Synthetic Method for Monodehydro-Cyclic-Dipeptides toward Natural Product Synthesis
• New Aspects of Potent Anti-Microtubule Agents Phenylahistin and Tubulin Photoaffinity Labeling
• P-518 DEVELOPMENT OF POTENT ANTI-MICROTUBULE AGENTS BASED ON NATURAL DIKETOPIPERAZINE PHENYLAHISTIN AND TUBULIN PHOTOAFFINITY LABELING
• Development of a New Synthetic Method for Monodehydro-2,5-diketopiperazines
• Synthetic Study of Anti-microtubule Diketopiperazines : Phenylahistin and Aurantiamine
• Studies on N^〈in〉-Protecting Groups during the Synthesis of Trp : Containing Cystine Peptide by Silyl Chloride Sulfoxide Method
• A Reductive Acidolysis Final Deprotection Strategy in Solid Phase Peptide Synthesis Based on Safety-Catch Protection
• Effect of Dipeptidomimetics on Malaria Parasite Proliferation Inhibition Targeting Plasmepsin
• 3P-061 溶液高分解能NMRによる凝集性タンパク質の新規構造解析法の開発(蛋白質・計測,解析の方法論,第46回日本生物物理学会年会)
• Synthesis of Human C-Type Natriuretic Peptide 22 Using Chlorotrityl Resin and Tetrafluoroboric Acid Deprotection
• Translocation of Basic Peptides through Human Cell Membranes
• SYNTHESES AND STRUCTURE-ACTIVITY RELATIONSHIPS OF SMALL-SIZED ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES
• Solid Phase Synthesis of a Mercaptoamide Peptide Using New Linkers
• Action Mechanism of a PEGylated Magainin Analogue Peptide
• Visualizing Internalization of Membrane Receptors Using New Fluorescence Labeling Method
• Synthetic Studies on 7TM-GPCR (I) : Lipid Bilayer Assisted Membrane Peptide Ligation
• Stability and Self-Association of a Model Transmembrane Helix in Lipid Bilayers
• Interactions of a Membrane-Spanning Model Peptide with Lipid Bilayers
• Membrane Insertion and Dissociation Processes of a Model Transmembrane Helix
• Inhibition of Amyloid β Peptide Fibril Formation by Hydrogel Nanoparticles
• Click Peptide : Application to E22Δ-type Mutant of Amyloid β Peptide
• Click Peptide : In Situ Production of pyroGlu-Abeta from the O-Acyl Isopeptide
• Use of O-Acyl Isopeptides to Identify New Functions of Amyloid β Peptides
• Formation of Toxic Aβ-(1-40) Fibrils on GM1 Ganglioside-containing Membranes Mimicking Lipid Rafts
• Design and Preparation of the Tetrapeptides as Low Molecular Sized BACE1 Inhibitors
• Screening Methodology for Discovery of Inhibitory Peptides against Pathogenic Proteins using a Plug-plug Affinity Capillary Electrophoresis Technique
• Optimization of Peptidomimetic Plasmepsin Inhibitor Containing Allophenylnorstatine Using Basic Substituent for Malaria Treatment
• Design of BACE1 Inhibitors Containing 5-Nitro-Isophthalamide
• Can the substrate of an enzyme turn into its inhibitor by vastly-reduced k_ value?
• Phenyl(cyclo)alkylamines : Second generation P_1' position analogs for pentapeptidic BACE1 inhibitors
• Tripeptidic BACE1 Inhibitors by Conformational Structure-based Design
• Structure Activity Relationship Study of SARS Coronavirus 3CL Protease Inhibitors with an Electrophilic Aryl Ketone Structure
• Synthesis and Biological Evaluation of Dipeptidic Antibiotics (+)-Negamycin and Its Derivatives for Development of Duchenne Muscular Dystrophy Chemotherapy
• Isotope Labeling-assisted Quantitative Evaluation of Refolding Conditions of a Recombinant Disulfide Protein
• Intact Cell-based SPR Analyses of Interactions between EGF and its Receptor
• Development of Chemical Probes towards the Elucidation of Binding Mechanism of Plinabulin, a Cyclicdipeptide Based Anti-microtubule Agent
• Novel BACE1 inhibitors containing P_1-P_1' non-natural amino acid-guanidinyl analogues
• Association-dissociation kinetics for dimerization of transmembrane helices as detected by single molecule fluorescence spectroscopy
• 1A1312 ガングリオシドクラスターを含むラフト様膜中でのAβのアミロイド形成機構(生体膜・人工膜1(構造・物性、ダイナミクス),第49回日本生物物理学会年会)
• Design, Synthesis and Evalution of Tripeptidomimetics with Arylketone as Inhibitors of SARS-CoV 3CL Protease
• Mechanism of Amyloid β-Protein Aggregation Mediated by GM1 Ganglioside Clusters
• Quantitative Analyses of Disulfide Bond Formation in Proteins Using ^O-Labeled Peptide Standards
• Design and SAR Study of Tripeptidic BACE1 Inhibitors

もっと見る 閉じる

スポンサーリンク