Can the substrate of an enzyme turn into its inhibitor by vastly-reduced k_<cat> value?
スポンサーリンク
概要
- 論文の詳細を見る
- 2011-03-01
著者
-
Kiso Y
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
-
木村 富美夫
Pharmaceutical Research Department Ube Laboratory Corporate Research & Development Ube Industrie
-
HAMADA Takashi
Department of Hepatobiliary Pancreatic and Transplant Surgery, Graduate School of Medicine, Mie Univ
-
HAMADA Yoshio
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, 21st Century C
-
Hayashi Yoshio
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
-
Kinoshita Yuko
Department Of Oriental Medicine Nihon University School Of Medicine
-
Kimura Tomio
Pharmaceutical Research Department Ube Laboratory Corporate Research & Development Ube Industrie
-
景山 節
京都大学霊長類研究所人類進化モデル研究センター
-
Kimura T
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
-
Kimura Tooru
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
-
Kiso Yoshiaki
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
-
Kiso Yoshiaki
21st Century Coe Program Kyoto Pharmaceutical University
-
Kiso Yoshiaki
Kyoto Pharmaceutical Univ. Kyoto Jpn
-
Hayashi Yoshio
Department Of Electrical And Electronic Engineering Kitami Institute Of Technology
-
Kiso Yoshiaki
Protein Research Group Riken Genomic Sciences Center
-
Yamaguchi H
Department Of Oral Molecular Pathology Institute Of Health Bioscience The University Of Tokushima Gr
-
Kimura Tooru
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut
-
TAGAD Harichandra
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmace
-
Hamada Takashi
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut
-
Tagad Harichandra
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut
-
Hayashi Yoshio
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut
-
Hamada Takashi
Department Of Hepatobiliary Pancreatic And Transplant Surgery Mie University School Of Medicine
-
Kimura T
Peptide Inst. Inc. Minoh Jpn
-
Hamada Takashi
Department Fo Systems Design Engineering Graduate School Of Engineering Kanazawa Institute Of Techno
-
KISO Yoshiaki
Department of Ecological Engineering, Toyohashi University of Technology, JAPAN.
-
HAMADA Yoshio
Department of Cardiovascular Surgery and Internal Medicine, Saiseikai Shimonoseki General Hospital
関連論文
- Tissue factor expression demonstrates severe sinusoidal endothelial cell damage during rejection after living-donor liver transplantation
- Development of New Photoresponsive Paclitaxel Prodrug
- Phototaxel : Development of First Photoresponsive Prodrug of Paclitaxel via Modification of Phenylisoserine Moiety
- "Click Peptide" : the "O-Acyl Isopeptide Method" for Peptide Synthesis and Development of Chemical Biology-Oriented Aβ Analogues
- "Click Peptide" Based on the "O-Acyl Isopeptide Method" : Development of Chemical Biology-Oriented Alzheimer's Disease-Related Aβ1-42 Analogues
- Design and Synthesis of Dipeptide-type HIV-1 Protease Inhibitors with High Antiviral Activity
- New Type Prodrugs of Anti-HIV Agents Consisting of the HIV Protease Inhibitor and Reverse Transcriptase Inhibitor
- Synthesis and Activity of a New Type of Anti-HIV Agents, Conjugate of HIV Protease Inhibitor with Reverse Transcriptase Inhibitor
- Synthesis of an HIV-1 Protease Analogue by the Chemoselective Ligation Method Using a New Disulfide Type Linker
- Racemization-Free Segment Condensation Based on Isopeptide Method : An Efficient Preparation of Peptides on Solid Support
- The Synthesis of Bioactive Peptides Based on O-Acyl Isopeptide Method : Application of O-Acyl Isodipeptide Units
- Development of Racemization-Free "O-Acyl Isopeptide Method" Utilizing the "O-Acyl Isodipeptide Unit"
- P-262 "O-ACYL ISOPEPTIDE METHOD" FOR THE EFFICIENT SYNTHESIS OF DIFFICULT SEQUENSE-CONTAINING PEPTIDES : UTILIZATION OF "O-ACYL ISODIPEPTIDE UNIT"
- Conversion of Polymer-Bound Dipeptide to Evans-Type Chiral Auxiliary : A New Tool for Efficient Solid-Phase Asymmetric Reactions
- Drastic Improvement in Wettability of 6,13-Bis(triisopropylsilylethynyl)pentacene by Addition of Silica Nanoparticles for Solution-Processable Organic Field-Effect Transistors
- Structure-Activity Relationship of Orally Potent Tripeptide-Based HIV Protease Inhibitors Containing Hydroxymethylcarbonyl Isostere
- Small-sized HIV Protease Inhibitors Containing Allophenylnorstatine as a Substrate Transition-state Mimic
- Design of HIV Protease Inhibitors Based on the Transition State Analogue Concept
- Novel 2-Amino-1,4-dihydropyridine Calcium Antagonists. II. Synthesis and Antihypertensive Effects of 2-Amino-1,4-dihydropyridine Derivatives Having N, N-Dialkylaminoalkoxycarbonyl Groups at 3- and/or 5-Position
- Novel 2-Amino-1,4-dihydropyridine Calcium Antagonists. I. Synthesis and Antihypertensive Effects of 2-Amino-1,4-dihydropyridine Derivatives Having Nitroxyalkoxycarbonyl Groups at 3- and/or 5-Position
- Fabrication and characterization of poly(3-hexylthiophene)-based field-effect transistors with silsesquioxane gate insulators
- Novel BACE1 Inhibitors : Design Approach Focused on Inhibitor's Conformer
- Structure-Activity Relationship Study of BACE1 Inhibitors Containing Chelidonamide
- Synthesis of HIV Protease Dipeptide Inhibitors and Prodrugs
- Oligoarginine-Based Prodrugs with Self-Cleavable Spacers for Caco-2 Cell Permeation
- Synthesis and Activity of Tetrapeptidic Human T-cell Leukemia Virus Type I Protease Inhibitors Possessing Different P_1'- and P_3-cap Moieties
- Design of BACE1 Inhibitors : Replacing the P_1' Residue with Non-Acidic Moiety
- Design and Synthesis of Conformationally Constrained Dimerization Inhibitors of HIV-1 Protease
- Synthesis of Negamycin and Its Derivatives as Potential Therapeutic Agents for Duchenne Muscular Dystrophy
- Structural Analysis of Amyloid-β Protein Fibrils Formed in Raft-Like Model Membranes
- Inhibition of Amyloid β-Protein Aβ-(1-42) Induced Cytotoxicity by Helical Aβ Analog
- Phenylthionorstatine as a Transition-State Mimic in BACE1 Inhibitors
- Tripeptide Mimetics with Potent Inhibitory Activity against Malarial Aspartic Protease Plasmepsin II
- P-296 DEVELOPMENT OF RESIN SUPPORTED EVANS-TYPE CHIRAL AUXILIARY FOR SOLID-PHASE ASYMMETRIC REACTION
- Modification of P4 Position in β-secretase (BACE1) Inhibitors Containing Phenylnorstatine
- Design of β-Secretase (BACE1) Inhibitors with Carboxylic Acid Bioisosteres
- Evaluation of Peptidomimetic HTLV-I Protease Inhibitors Containing Hydroxymethylcarbonyl as a Transition-State Isostere
- O-N Intramolecular Acyloxy Migration Reaction : from the Prodrug Strategy to the Migration of Protective Groups in Amino Acids
- "Click Peptide" Based on the "O-Acyl Isopeptide Method" : an Efficient Preparation of Amyloid β Peptide 1-42 Mutants
- Portable Type Signal-Averaged Electrocardiography With Dipyridamole : A New and Convenient Method to Detect Patients With Coronary Artery Disease and Ischemia
- SYNTHESES AND STRUCTURE-ACTIVITY RELATIONSHIPS OF ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES
- High-throughput Screening Method for Ligand Peptides Using Capillary Electrophoresis-Mass Spectrometry (CE-MS)
- A Novel S-Acyl Isopeptide Method for the Synthesis of Difficult Sequence-Containing Peptide
- Isopeptide Method : A Racemization-Free Peptide Synthesis by Segment Condensation
- Design and Synthesis of Inhibitory Peptides against EGF Receptor Dimerization
- SAR study of BACE1 inhibitors containing pyridine derivatives
- Significance of interaction of BACE1-Arg235 with its ligands and design of BACE1 inhibitors
- Chemical Synthesis of 71-meric Neuregulin 1-β1
- Click Peptide by Use of the O-Acyl Isopeptide Method : Production of Amyloid β Peptide from Water-Soluble Analogue
- "O-Acyl Isopeptide Method" for the Synthesis of Difficult Sequence-Containing Peptides : Application to the Synthesis of Amyloid β Peptide (Aβ) 1-42
- Development of Biotin-Tagged Tubulin Photoaffinity Probes Derivatized from Diketopiperazine Based Anti-Microtubule Agents
- Effect of the Phenyl Ring Modification on the Antitumor Activity of Anti-Microtubule Agent Dehydrophenylahistin
- Uptake Mechanisms of FITC-Oligoarginine Conjugates in HeLa Cells
- Design and Synthesis of Oligoarginine-Fluorescein Conjugates Possessing Novel Self-Cleavable Spacers as a Model for Effective Intestinal Absorption
- Efficient Total Synthesis of (+)-Negamycin and Its Derivatives
- Small Peptide-based Medicinal Chemistry for Intractable Disease
- A Synthetic Method for Monodehydro-Cyclic-Dipeptides toward Natural Product Synthesis
- New Aspects of Potent Anti-Microtubule Agents Phenylahistin and Tubulin Photoaffinity Labeling
- P-518 DEVELOPMENT OF POTENT ANTI-MICROTUBULE AGENTS BASED ON NATURAL DIKETOPIPERAZINE PHENYLAHISTIN AND TUBULIN PHOTOAFFINITY LABELING
- Development of a New Synthetic Method for Monodehydro-2,5-diketopiperazines
- Synthetic Study of Anti-microtubule Diketopiperazines : Phenylahistin and Aurantiamine
- Studies on N^〈in〉-Protecting Groups during the Synthesis of Trp : Containing Cystine Peptide by Silyl Chloride Sulfoxide Method
- A Reductive Acidolysis Final Deprotection Strategy in Solid Phase Peptide Synthesis Based on Safety-Catch Protection
- Effect of Dipeptidomimetics on Malaria Parasite Proliferation Inhibition Targeting Plasmepsin
- Design and Synthesis of Highly Active β-Secretase (BACE1) inhibitors, KMI-420 and KMI-429, with Enhanced Chemical Stability
- Evaluation of Peptidomimetic Inhibitors against Malarial Protease Plasmepsin
- Dipeptide-Type Inhibitors Targeting Plasmepsins from Plasmodium Falciparum
- Analysis of Side Reaction in the Amide Bond Formation with an α-Hydroxy-β-amino Acid as an Acyl Componemt
- Synthesis of Human C-Type Natriuretic Peptide 22 Using Chlorotrityl Resin and Tetrafluoroboric Acid Deprotection
- O-N Intramolecular Acyl and Acyloxy Migration Reaction in the Development of Water-Soluble Prodrugs of Taxoids
- Development of New Water-Soluble Prodrugs Based on Intramolecular Nucleophilic Reactions in Peptide Chemistry
- SYNTHESES AND STRUCTURE-ACTIVITY RELATIONSHIPS OF SMALL-SIZED ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES
- Solid Phase Synthesis of a Mercaptoamide Peptide Using New Linkers
- Delivery of small interfering RNA with a synthetic collagen poly (Pro-Hyp-Gly) for gene silencing in vitro and in vivo
- Development of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) after pancreaticoduodenectomy : proposal of a postoperative NAFLD scoring system
- Total vascular hepatic exclusion for tumor resection : a new approach to the intrathoracic inferior vena cava through the abdominal cavity by cutting the diaphragm vertically without cutting the pericardium
- Atelocollagen-mediated systemic administration of myostatin-targeting siRNA improves muscular atrophy in caveolin-3-deficient mice
- Click Peptide : Application to E22Δ-type Mutant of Amyloid β Peptide
- Click Peptide : In Situ Production of pyroGlu-Abeta from the O-Acyl Isopeptide
- Use of O-Acyl Isopeptides to Identify New Functions of Amyloid β Peptides
- Design and Preparation of the Tetrapeptides as Low Molecular Sized BACE1 Inhibitors
- Screening Methodology for Discovery of Inhibitory Peptides against Pathogenic Proteins using a Plug-plug Affinity Capillary Electrophoresis Technique
- Development of a Solid-supported Biotinylation Reagent for the Efficient Biotin Labeling to the SH group of Peptides and Small Molecules
- Optimization of Peptidomimetic Plasmepsin Inhibitor Containing Allophenylnorstatine Using Basic Substituent for Malaria Treatment
- Design of BACE1 Inhibitors Containing 5-Nitro-Isophthalamide
- Can the substrate of an enzyme turn into its inhibitor by vastly-reduced k_ value?
- Phenyl(cyclo)alkylamines : Second generation P_1' position analogs for pentapeptidic BACE1 inhibitors
- Tripeptidic BACE1 Inhibitors by Conformational Structure-based Design
- Structure Activity Relationship Study of SARS Coronavirus 3CL Protease Inhibitors with an Electrophilic Aryl Ketone Structure
- Synthesis and Biological Evaluation of Dipeptidic Antibiotics (+)-Negamycin and Its Derivatives for Development of Duchenne Muscular Dystrophy Chemotherapy
- Isotope Labeling-assisted Quantitative Evaluation of Refolding Conditions of a Recombinant Disulfide Protein
- Intact Cell-based SPR Analyses of Interactions between EGF and its Receptor
- Development of Chemical Probes towards the Elucidation of Binding Mechanism of Plinabulin, a Cyclicdipeptide Based Anti-microtubule Agent
- Novel BACE1 inhibitors containing P_1-P_1' non-natural amino acid-guanidinyl analogues
- Monitoring peripheral blood CD4+ adenosine triphosphate activity after living donor liver transplantation : impact of combination assays of immune function and CYP3A5 genotype
- Design, Synthesis and Evalution of Tripeptidomimetics with Arylketone as Inhibitors of SARS-CoV 3CL Protease
- Quantitative Analyses of Disulfide Bond Formation in Proteins Using ^O-Labeled Peptide Standards
- Novel Neutrophil-Activating Cryptides Hidden in Mitochondrial Cytochrome c : Identification and Structure-Activity Studies
- Design and SAR Study of Tripeptidic BACE1 Inhibitors
- Development of (+)-Negamycin Derivatives with Potent Readthrough Activity for Duchenne Muscular Dystrophy Chemotherapy