Hayashi Yoshio | Department Of Medicinal Chemistry Kyoto Pharmaceutical University

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概要

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著作論文

Oligoarginine-Based Prodrugs with Self-Cleavable Spacers for Caco-2 Cell Permeation
Design and Synthesis of Conformationally Constrained Dimerization Inhibitors of HIV-1 Protease
Synthesis of Negamycin and Its Derivatives as Potential Therapeutic Agents for Duchenne Muscular Dystrophy
SAR study of BACE1 inhibitors containing pyridine derivatives
Significance of interaction of BACE1-Arg235 with its ligands and design of BACE1 inhibitors
Click Peptide by Use of the O-Acyl Isopeptide Method : Production of Amyloid β Peptide from Water-Soluble Analogue
Development of Biotin-Tagged Tubulin Photoaffinity Probes Derivatized from Diketopiperazine Based Anti-Microtubule Agents
Uptake Mechanisms of FITC-Oligoarginine Conjugates in HeLa Cells
Design and Synthesis of Oligoarginine-Fluorescein Conjugates Possessing Novel Self-Cleavable Spacers as a Model for Effective Intestinal Absorption
Efficient Total Synthesis of (+)-Negamycin and Its Derivatives
Analysis of Side Reaction in the Amide Bond Formation with an α-Hydroxy-β-amino Acid as an Acyl Componemt
Delivery of small interfering RNA with a synthetic collagen poly (Pro-Hyp-Gly) for gene silencing in vitro and in vivo
Atelocollagen-mediated systemic administration of myostatin-targeting siRNA improves muscular atrophy in caveolin-3-deficient mice
Design and Preparation of the Tetrapeptides as Low Molecular Sized BACE1 Inhibitors
Development of a Solid-supported Biotinylation Reagent for the Efficient Biotin Labeling to the SH group of Peptides and Small Molecules
Design of BACE1 Inhibitors Containing 5-Nitro-Isophthalamide
Can the substrate of an enzyme turn into its inhibitor by vastly-reduced k_ value?
Phenyl(cyclo)alkylamines : Second generation P_1' position analogs for pentapeptidic BACE1 inhibitors
Tripeptidic BACE1 Inhibitors by Conformational Structure-based Design
Structure Activity Relationship Study of SARS Coronavirus 3CL Protease Inhibitors with an Electrophilic Aryl Ketone Structure
Synthesis and Biological Evaluation of Dipeptidic Antibiotics (+)-Negamycin and Its Derivatives for Development of Duchenne Muscular Dystrophy Chemotherapy
Development of Chemical Probes towards the Elucidation of Binding Mechanism of Plinabulin, a Cyclicdipeptide Based Anti-microtubule Agent
Novel BACE1 inhibitors containing P_1-P_1' non-natural amino acid-guanidinyl analogues
Design, Synthesis and Evalution of Tripeptidomimetics with Arylketone as Inhibitors of SARS-CoV 3CL Protease
Design and SAR Study of Tripeptidic BACE1 Inhibitors
Development of (+)-Negamycin Derivatives with Potent Readthrough Activity for Duchenne Muscular Dystrophy Chemotherapy

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