"Click Peptide" Based on the "O-Acyl Isopeptide Method" : Development of Chemical Biology-Oriented Alzheimer's Disease-Related Aβ1-42 Analogues
スポンサーリンク
概要
- 論文の詳細を見る
- 2006-03-01
著者
-
木村 富美夫
Pharmaceutical Research Department Ube Laboratory Corporate Research & Development Ube Industrie
-
Hirota Shun
Graduate School Of Materials Science Nara Institute Of Science And Technology
-
KIMURA Tooru
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Centur
-
HAYASHI Yoshio
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Centur
-
KISO Yoshiaki
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Centur
-
SOHMA Youhei
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science and 21st Centur
-
TANIGUCHI Atsuhiko
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmace
-
FUKAO Fukue
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmace
-
CHIYOMORI Yousuke
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmace
-
MATSUZAKI Katsumi
Graduate School of Pharmaceutical Sciences, Kyoto University
-
KIMURA Maiko
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmace
-
OKADA Takuma
Graduate School of Pharmaceutical Sciences, Kyoto University
-
IKEDA Keisuke
Graduate School of Pharmaceutical Sciences, Kyoto University
-
HIROTA Shun
Physical Chemistry, 21st Century COE Program, Kyoto Pharmaceutical University
-
Ikeda Keisuke
Graduate School Of Pharmaceutical Sciences Kyoto University
-
CHIYOMORI Yousuke
Kyoto Pharmaceutical University
-
Kimura T
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
-
Kimura Maiko
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
-
Fukao Fukue
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
-
Kimura Maiko
Department Of Human Sciences School Of Letters Mukogawa Women's University
-
Sohma Youhei
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
-
Okada Takuma
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Kiso Yoshiaki
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
-
Ikeda Keisuke
Institute For Protein Research Osaka University
-
Taniguchi Atsuhiko
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe
-
Hayashi Yoshio
Department Of Electrical And Electronic Engineering Kitami Institute Of Technology
-
Matsuzaki Katsumi
Graduate School Of Pharmaceutical Sciences Kyoto University
-
Matsuzaki Katsumi
Graduate School Of Biostudies Kyoto University
-
Yamaguchi H
Department Of Oral Molecular Pathology Institute Of Health Bioscience The University Of Tokushima Gr
-
Kimura Tooru
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut
-
Chiyomori Yousuke
Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut
-
Ikeda Keisuke
Graduate School Of Agriculture Hokkaido University
-
Kimura T
Peptide Inst. Inc. Minoh Jpn
-
Hayashi Yoshio
Department Of Chemistry Faculty Of Science Kanazawa University
-
Hirota Shun
Graduate School of Materials Science, Nara Institute of Science and Technology
-
KISO Yoshiaki
Department of Ecological Engineering, Toyohashi University of Technology, JAPAN.
関連論文
- Development of New Photoresponsive Paclitaxel Prodrug
- Phototaxel : Development of First Photoresponsive Prodrug of Paclitaxel via Modification of Phenylisoserine Moiety
- "Click Peptide" : the "O-Acyl Isopeptide Method" for Peptide Synthesis and Development of Chemical Biology-Oriented Aβ Analogues
- "Click Peptide" Based on the "O-Acyl Isopeptide Method" : Development of Chemical Biology-Oriented Alzheimer's Disease-Related Aβ1-42 Analogues
- Design and Synthesis of Dipeptide-type HIV-1 Protease Inhibitors with High Antiviral Activity
- Controlled Drug Release : Design and Application of New Water-soluble Prodrugs
- Spontaneously Regenerable Prodrug : Design and Synthesis of Water-soluble Prodrugs of HIV Protease Inhibitors
- Design of Double-Drug-Type Anti-HIV Agents
- New Type Prodrugs of Anti-HIV Agents Consisting of the HIV Protease Inhibitor and Reverse Transcriptase Inhibitor
- Synthesis and Activity of a New Type of Anti-HIV Agents, Conjugate of HIV Protease Inhibitor with Reverse Transcriptase Inhibitor
- Synthesis of an HIV-1 Protease Analogue by the Chemoselective Ligation Method Using a New Disulfide Type Linker
- Racemization-Free Segment Condensation Based on Isopeptide Method : An Efficient Preparation of Peptides on Solid Support
- The Synthesis of Bioactive Peptides Based on O-Acyl Isopeptide Method : Application of O-Acyl Isodipeptide Units
- Development of Racemization-Free "O-Acyl Isopeptide Method" Utilizing the "O-Acyl Isodipeptide Unit"
- P-262 "O-ACYL ISOPEPTIDE METHOD" FOR THE EFFICIENT SYNTHESIS OF DIFFICULT SEQUENSE-CONTAINING PEPTIDES : UTILIZATION OF "O-ACYL ISODIPEPTIDE UNIT"
- Conversion of Polymer-Bound Dipeptide to Evans-Type Chiral Auxiliary : A New Tool for Efficient Solid-Phase Asymmetric Reactions
- 3P023 C末端ヘリックスの連続ドメインスワッピングによるシトクロムcポリマー化(蛋白質-構造,第48回日本生物物理学会年会)
- Revised Japanese criteria for Sjogren's syndrome (1999) : availability and validity
- 1P120 1I1240 1分子蛍光計測による膜貫通ヘリックス間相互作用揺らぎの検出(膜蛋白質,口頭発表,第48回日本生物物理学会年会)
- FEM-Based Electromagnetic Wave Simulator Running on Some Platforms by Use of Java and a Commercial Tool(Analytical and Simulation Methods for Electromagnetic Wave Problems)
- FEM-Based Electromagnetic Wave Simulator Running on Some Platforms by Use of Java and a Commercial Tool
- Development of Spontaneously Regenerable Water-Soluble Prodrugs Based on the Peptide Chemistry : Importance of Drug Release Time for the Improvement of Gastrointestinal Absorption
- Properties of Intracellular Fragment Peptides of Mouse Prostaglandin E_2 Receptor EP3 Isoform
- Structure-Activity Relationship of Orally Potent Tripeptide-Based HIV Protease Inhibitors Containing Hydroxymethylcarbonyl Isostere
- Small-sized HIV Protease Inhibitors Containing Allophenylnorstatine as a Substrate Transition-state Mimic
- Design of HIV Protease Inhibitors Based on the Transition State Analogue Concept
- Metastatic Prostate Carcinoma to the Mandible : Report of a case
- Malignant Melanoma in situ of the Lower Lip
- Novel 2-Amino-1,4-dihydropyridine Calcium Antagonists. II. Synthesis and Antihypertensive Effects of 2-Amino-1,4-dihydropyridine Derivatives Having N, N-Dialkylaminoalkoxycarbonyl Groups at 3- and/or 5-Position
- Novel 2-Amino-1,4-dihydropyridine Calcium Antagonists. I. Synthesis and Antihypertensive Effects of 2-Amino-1,4-dihydropyridine Derivatives Having Nitroxyalkoxycarbonyl Groups at 3- and/or 5-Position
- Elucidation of Membrane Protein Folding Using Model Transmembrane Helices
- Novel BACE1 Inhibitors : Design Approach Focused on Inhibitor's Conformer
- Structure-Activity Relationship Study of BACE1 Inhibitors Containing Chelidonamide
- Synthesis of HIV Protease Dipeptide Inhibitors and Prodrugs
- Oligoarginine-Based Prodrugs with Self-Cleavable Spacers for Caco-2 Cell Permeation
- Synthesis and Activity of Tetrapeptidic Human T-cell Leukemia Virus Type I Protease Inhibitors Possessing Different P_1'- and P_3-cap Moieties
- Design of BACE1 Inhibitors : Replacing the P_1' Residue with Non-Acidic Moiety
- Design and Synthesis of Conformationally Constrained Dimerization Inhibitors of HIV-1 Protease
- Synthesis of Negamycin and Its Derivatives as Potential Therapeutic Agents for Duchenne Muscular Dystrophy
- Phenylthionorstatine as a Transition-State Mimic in BACE1 Inhibitors
- Tripeptide Mimetics with Potent Inhibitory Activity against Malarial Aspartic Protease Plasmepsin II
- P-296 DEVELOPMENT OF RESIN SUPPORTED EVANS-TYPE CHIRAL AUXILIARY FOR SOLID-PHASE ASYMMETRIC REACTION
- Modification of P4 Position in β-secretase (BACE1) Inhibitors Containing Phenylnorstatine
- Design of β-Secretase (BACE1) Inhibitors with Carboxylic Acid Bioisosteres
- Convenient and Regioselective Syntheses of 3, 4-Disubsutituted Δ^3-Pyrrolin-2-one Derivatives Starting from 2-Tosyl-3, 4-Disubstituted Pyrroles
- Evaluation of Peptidomimetic HTLV-I Protease Inhibitors Containing Hydroxymethylcarbonyl as a Transition-State Isostere
- O-N Intramolecular Acyloxy Migration Reaction : from the Prodrug Strategy to the Migration of Protective Groups in Amino Acids
- "Click Peptide" Based on the "O-Acyl Isopeptide Method" : an Efficient Preparation of Amyloid β Peptide 1-42 Mutants
- 2P-054 レーザーフラッシュフォトリシス法による節足動物由来ヘモシアニンのアロステリック効果の研究(蛋白質・構造機能相関(2),第46回日本生物物理学会年会)
- Design and Synthesis of β-Secretase Inhibitors Containing Hydroxymethylcarbonyl Isostere as a Transition State Mimic
- SYNTHESES AND STRUCTURE-ACTIVITY RELATIONSHIPS OF ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES
- A Novel S-Acyl Isopeptide Method for the Synthesis of Difficult Sequence-Containing Peptide
- Isopeptide Method : A Racemization-Free Peptide Synthesis by Segment Condensation
- Three-dimensional Quantitative Structure-Activity Relationship Analysis of RGD Mimetics as Fibrinogen Receptor Antagonists
- Synthesis and Biological Activities of Phenylahistin Derivatives
- Design and Synthesis of Inhibitory Peptides against EGF Receptor Dimerization
- SAR study of BACE1 inhibitors containing pyridine derivatives
- Significance of interaction of BACE1-Arg235 with its ligands and design of BACE1 inhibitors
- Chemical Synthesis of 71-meric Neuregulin 1-β1
- The Rate of Cell Growth Is Regulated by Purine Biosynthesis via ATP Production and G1 to S Phase Transition
- Mechanisms of Transfer into SCID Mice Reconstituted with Tissueinfiltrating Cells from Murine Model for Sjogren's Syndrome
- Large Cell Undifferentiated Carcinoma of the Parotid Gland Containing Malignant Oncocytic Change
- Click Peptide by Use of the O-Acyl Isopeptide Method : Production of Amyloid β Peptide from Water-Soluble Analogue
- "O-Acyl Isopeptide Method" for the Synthesis of Difficult Sequence-Containing Peptides : Application to the Synthesis of Amyloid β Peptide (Aβ) 1-42
- Effect of the Phenyl Ring Modification on the Antitumor Activity of Anti-Microtubule Agent Dehydrophenylahistin
- Uptake Mechanisms of FITC-Oligoarginine Conjugates in HeLa Cells
- Design and Synthesis of Oligoarginine-Fluorescein Conjugates Possessing Novel Self-Cleavable Spacers as a Model for Effective Intestinal Absorption
- Efficient Total Synthesis of (+)-Negamycin and Its Derivatives
- Small Peptide-based Medicinal Chemistry for Intractable Disease
- A Synthetic Method for Monodehydro-Cyclic-Dipeptides toward Natural Product Synthesis
- New Aspects of Potent Anti-Microtubule Agents Phenylahistin and Tubulin Photoaffinity Labeling
- P-518 DEVELOPMENT OF POTENT ANTI-MICROTUBULE AGENTS BASED ON NATURAL DIKETOPIPERAZINE PHENYLAHISTIN AND TUBULIN PHOTOAFFINITY LABELING
- Development of a New Synthetic Method for Monodehydro-2,5-diketopiperazines
- Synthetic Study of Anti-microtubule Diketopiperazines : Phenylahistin and Aurantiamine
- Studies on N^〈in〉-Protecting Groups during the Synthesis of Trp : Containing Cystine Peptide by Silyl Chloride Sulfoxide Method
- A Reductive Acidolysis Final Deprotection Strategy in Solid Phase Peptide Synthesis Based on Safety-Catch Protection
- Effect of Dipeptidomimetics on Malaria Parasite Proliferation Inhibition Targeting Plasmepsin
- Design and Synthesis of Highly Active β-Secretase (BACE1) inhibitors, KMI-420 and KMI-429, with Enhanced Chemical Stability
- Evaluation of Peptidomimetic Inhibitors against Malarial Protease Plasmepsin
- Dipeptide-Type Inhibitors Targeting Plasmepsins from Plasmodium Falciparum
- Analysis of Side Reaction in the Amide Bond Formation with an α-Hydroxy-β-amino Acid as an Acyl Componemt
- Substrate Transition-State Analogue Inhibitors of Plasmepsin II as Antimalarial Drugs
- An Approach for Peptidic Aspartic Protease Inhibitors Using Ala-containing Oligopeptides Independent of the Substrate Sequence
- Development of a New Synthetic Method for L-Tetrahydrofuranylglycine and Its Application for Substrate-based HIV-1 Protease Inhibitors
- Synthesis of Human C-Type Natriuretic Peptide 22 Using Chlorotrityl Resin and Tetrafluoroboric Acid Deprotection
- Carcinoma in Pleomorphic Adenoma of the Tongue : Report of a case
- O-N Intramolecular Acyl and Acyloxy Migration Reaction in the Development of Water-Soluble Prodrugs of Taxoids
- SYNTHESES AND STRUCTURE-ACTIVITIES RELATIONSHIPS OF SMALLSIZED ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES WITH POTENT ACTIVITY
- SYNTHESES AND STRUCTURE-ACTIVITY RELATIONSHIPS OF SMALL-SIZED ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES
- Solid Phase Synthesis of a Mercaptoamide Peptide Using New Linkers
- SYNTHESES OF CYSTINE-PEPTIDES BY A NEW DISULPHIDE BOND FORMING REACTION
- Delivery of small interfering RNA with a synthetic collagen poly (Pro-Hyp-Gly) for gene silencing in vitro and in vivo
- Epitope mapping of anti-α-fodrin antibody in a case of early-onset multiple sclerosis
- Design and Preparation of the Tetrapeptides as Low Molecular Sized BACE1 Inhibitors
- Optimization of Peptidomimetic Plasmepsin Inhibitor Containing Allophenylnorstatine Using Basic Substituent for Malaria Treatment
- Design of BACE1 Inhibitors Containing 5-Nitro-Isophthalamide
- Can the substrate of an enzyme turn into its inhibitor by vastly-reduced k_ value?
- Phenyl(cyclo)alkylamines : Second generation P_1' position analogs for pentapeptidic BACE1 inhibitors
- Tripeptidic BACE1 Inhibitors by Conformational Structure-based Design
- 2SJ-03 ドメインスワッピングによるシトクロムcポリマー化(2SJ タンパク質複合体研究の新展開:分子から超分子、凝集体まで,日本生物物理学会第49回年会(2011年度))