Novel 2-Amino-1,4-dihydropyridine Calcium Antagonists. I. Synthesis and Antihypertensive Effects of 2-Amino-1,4-dihydropyridine Derivatives Having Nitroxyalkoxycarbonyl Groups at 3- and/or 5-Position

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概要

• 論文の詳細を見る

• Novel 2-amino-1,4-dihydropyridine derivatives, which contain nitroxy-alkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their pharmaceutical effect was evaluated in spontaneously hypertensive rats. The structure-activity relationships are discussed in terms of potency, onset-rapidity, and duration of antihypertensive activity. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced on either side of an ester chain.

• 公益社団法人日本薬学会の論文
• 1995-05-15

著者

• 井上 哲也

  Faculty Of Pharmaceutical Sciences Osaka University

• Kobayashi T

  Faculty Of Science Shinshu University

• 木村 富美夫

  Pharmaceutical Research Department Ube Laboratory Corporate Research & Development Ube Industrie

• 大泉 喜代志

  Sankyo Biological Research Laboratories, Sankyo Co., Ltd.

• 井上 勗

  Ohmiya Research Laboratory Fuji Yakuhin Co. Ltd.

• Inoue T

  Ohmiya Research Laboratory Fuji Yakuhin Co. Ltd

• Kawanishi T

  大妻女子大学 食物学科

• 古林 隆司

  Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries

• 井上 輝比古

  Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries

• 西野 繁栄

  Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries

• 北 純一郎

  Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries

• 吉屋 晴夫

  Pharmaceutical Research Department, Ube Laboratory, Corporate Research & Development, Ube Industries

• 西野 重孝

  New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Nishino S

  Fujisawa Pharmaceutical Co. Ltd. Osaka Jpn

• Kimura T

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• 西野 繁栄

  Pharmaceutical Research Department Ube Laboratory Corporate Research & Development Ube Industrie

• Inoue T

  Osaka University Of Pharmaceutical Sciences

• 井上 輝比古

  Pharmaceutical Research Department Ube Laboratory Corporate Research & Development Ube Industrie

• 大泉 喜代志

  Sankyo Pharmacology And Molecular Biology Research Laboratories Sankyo Co. Ltd.

• Oizumi K

  Sankyo Pharmacology And Molecular Biology Research Laboratories Sankyo Co. Ltd.

• 大泉 喜代志

  Sankyo Biological Research Laboratories Sankyo Co. Ltd.

• 吉屋 晴夫

  Pharmaceutical Research Department Ube Laboratory Corporate Research & Development Ube Industrie

• 北 純一郎

  Pharmaceutical Research Department Ube Laboratory Corporate Research & Development Ube Industrie

• Inoue Takao

  Faculty Of Pharmaceutical Sciences Hoshi University

• Kimura T

  Peptide Inst. Inc. Minoh Jpn

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