Studies on Antiulcer Drugs. IV. Synthesis and Antiulcer Activities of Imidazo[1,2-α]pyridinyl-ethylbenzothiazoles and -benzimidazoles
スポンサーリンク
概要
- 論文の詳細を見る
A series of 6-[2-(imidazo[1,2-α]pyridin-2-yl)ethyl]benzothiazoles (II) and benzimidazole analogues (III) was synthesized and tested for histamine H_2-receptor antagonist, gastric antisecretory and anti-stress ulcer activity. A benzimidazole derivative (IIIa) exhibited strong antisecretory activity, whereas the corresponding benzothiazole derivative (IIb) lacked this potency in in vivo test. In contrast to compound IIIa, however, compound IIb demonstrated good inhibition against stress induced ulcer. The structure-activity relationships of these compounds are discussed.
- 公益社団法人日本薬学会の論文
- 1992-07-25
著者
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桂 洋介
New Drung Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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井上 善一
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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友井 正明
Product Development Laboratories
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桂 洋介
New Drung Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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井上 善一
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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NISHINO Shigetaka
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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西野 重孝
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Nishino S
Fujisawa Pharmaceutical Co. Ltd. Osaka Jpn
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友井 正明
Product Development Laboratories Fujisawa Pharmaceutical Co. Ltd.
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