Studies on Cerebral Protective Agents. IV.Synthesis of Novel 4-Arylpyridine and 4-Arylpyridazine Derivatives with Anti-anoxic Activity
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概要
- 論文の詳細を見る
In a search for new cerebral protective agents, a series of 4-(3- or 4-nitrophenyl)-6-phenylpyridines (or pyridazines) and 2-(3-nitrophenyl)-6-phenylpyridines, possessing an amino moiety at the C-3 position of the pyridine(or pyridazine) ring, were synthesized through the corresponding novel 1,4-dihydro derivatives and tested for anti-anoxic (AA) activity in mice. Four compounds (2c, 2f, 3a, 4a) possessed significant AA activity at a dose of 32 mg/kg, i.p. These results suggest that four-atom linkages between the C-3 position of the pyridine (or pyridazine)ring and the nitrogeneous basic moiety also seems to be a prerequisite for the expression of AA activity.
- 公益社団法人日本薬学会の論文
- 1993-01-15
著者
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久野 敦司
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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酒井 裕義
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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杉山 良恵
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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酒井 裕義
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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杉山 良恵
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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久野 敦司
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Sakai H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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