Studies on Antiplatelet Agents. I. Synthesis and Platelet Inhibitory Activity of 5-Alkyl-2-aryl-4-pyridylimidazoles
スポンサーリンク
概要
- 論文の詳細を見る
5-Alkyl-2-aryl-4-pyridylimidazoles were synthesized and tested in rat ex vivo platelet aggregation studies. Among these compounds, 2-(2-fluorophenyl)-5-methyl-4-(3-pyridyl)imidazole (25) was most potent, and showed 98% inhibition at a dose of 10 mg/kg (p.o.). 25 had inhibitory activity on cyclooxygenase, thromboxane A_2 (TXA_2) synthetsase, and phosphodiesterase, and also showed inhibited KCl-induced contraction of rat aorta. All compounds have little acute toxicity and appear to be free of adverse effects on the stomach.
- 社団法人日本薬学会の論文
- 1992-12-25
著者
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伊藤 清隆
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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西野 重孝
New Drug Research Laboratories
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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田中 明人
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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元山 行雄
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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西野 重孝
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Nishino S
Fujisawa Pharmaceutical Co. Ltd. Osaka Jpn
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元山 行雄
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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田中 明人
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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