Studies on Cerebral Protective Agents. I. Novel 4-Arylpyrimidine Derivatives with Anti-anoxic and Anti-lipid Peroxidation Activities
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概要
- 論文の詳細を見る
Novel 4-arylpyrimidine derivatives were synthesized by the oxidation of 4-aryl-1,4-dyhydropyrimidines, and their effects on anti-anoxic (AA) activity in mice and anti-lipid peroxidation (ALP) activity in rat mitochondria were investigated. Among these compounds, ethyl 6-methyl-2-phenyl-4-(4-pyridyl)-5-pyrimidinecarboxylate (4b) has AA activity (10mg/kg, i.p.) and ethyl 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylate (4f) has ALP activity (73% inhibition at 10<-5>g/ml). The latter compound (100mg/kg, i.p.) was also effective on arachidonate-induced cerebral edema in rats with comparable potency to that of vitamin E.
- 公益社団法人日本薬学会の論文
- 1992-06-25
著者
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久野 敦司
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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勝田 清貴
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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杉山 良恵
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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勝田 清貴
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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杉山 良恵
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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上谷 利治
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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久野 敦司
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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