Studies on Cerebral Protective Agents. V.Novel 4-(3-Nitrophenyl)pyridine and 4-(3-Nitrophenyl)pyrimidine Derivatives with Anti-anoxic Activity
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概要
- 論文の詳細を見る
Novel 4-(3-nitrophenyl)pyridine and 4-(3-nitrophenyl)pyrimidine derivatives, possessing three-atom linkages between basic nitrogen and at the C-5 (or C-3) position of the pyrimidine (or pyridine) ring, were synthesized and tested for anti-anoxic (AA) activity in mice. Among them, 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-(pyrrolidinomethylcarbonyl-amino)pyrimidine (10f) had the most potent AA activity (3.2 mg/kg, i.p.). Three-dimensional molecular electrostatic potentials (3D-MEP) around the nitrogeneous basic moiety of 6-methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenylpyrimidine (FK 360) and 10f were compared. The negative zone of 10f is broader and deeper and positioned somewhat differently to that of FK 360,although there is a co-occupied spacial area in part.
- 社団法人日本薬学会の論文
- 1993-01-15
著者
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大久保 充
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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久野 敦司
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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酒井 裕義
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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酒井 裕義
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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久野 敦司
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Sakai H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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