Studies on Antiulcer Drugs. V. Synthesis and Antiulcer Activity of Aralkylbenzazoles
スポンサーリンク
概要
- 論文の詳細を見る
A series of 2-alkylamino-5- or 6-aralkyl-substituted benzazoles were synthesized and tested for histamine H_2-receptor antagonist and anti-stress ulcer activities. These new compounds showed little or no histamine H_2-receptor antagonist activity in contrast to imidazo[1,2-α]pyridine analogues (I). On antiulcer assay, however, some pyridine derivatives (II) exerted higher activity than the reference compounds, sofalcone, sucralfate and cimetidine. The structure-activity relationships of these compounds are discussed.
- 公益社団法人日本薬学会の論文
- 1992-08-25
著者
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桂 洋介
New Drung Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co., Ltd.,
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井上 善一
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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友井 正明
Product Development Laboratories
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桂 洋介
New Drung Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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高杉 寿
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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井上 善一
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd
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Takasugi H
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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友井 正明
Product Development Laboratories Fujisawa Pharmaceutical Co. Ltd.
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