New 2-Aryliminoimidazolidines. II. Synthesis and Antihypertensive Activity of 2-(Biphenylimino)-imidazolidines
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概要
- 論文の詳細を見る
For improvement of the duration of action of FR35447 (I), 2-(biphenylimino)imidazolidines (III) were synthesized and their hypotensive activity was tested against conscious normotensive rats. 2-(4'-Fluoro-[1,1'-biphenyl]-2-ylimino)imidazolidine (III l) exhibited superior hypotensive potency and was comparable to clonidine (II) in its duration of action.The structure-activity relationships of III are also described.
- 社団法人日本薬学会の論文
- 1992-01-25
著者
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松尾 昌昭
New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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植田 育男
Institute Of Scientific And Industrial Reseach Osaka University
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谷口 清
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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桂 洋介
New Drung Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.,
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植田 育男
(Present address)The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osa
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桂 洋介
New Drung Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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松尾 昌昭
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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