Reaction of 4-(N, N-Dimethylamino)-2-phenyl-2-(2-pyridyl)butanenitrile and Related Compounds with Ethyl Chloroformate; Formation of Indolizinium and Quinolizinium Chlorides
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概要
- 論文の詳細を見る
4-(N, N-Dialkylamino)-2-phenyl-2-(2-pyridyl)butanenitriles (10,11 and 12) and 5-(N, N-dimethylamino)-2-phenyl-2-(2-pyridyl)pentanenitrile (13) react with ethyl chloroformate, via a cyclization-N-dealkylation process, to give indolizinium and quinolizinium salts (1 and 2). Compounds 1 and 2 are also obtained by reaction of the alcohol derivatives 14 and 15 with thionyl chloride. Reaction of 2-phenyl-2-(2-pyridyl)ethanenitrile (9) in the presence of potassium hydroxide in dimethyl sulfoxide, leading to [2-hydroxy-2-phenyl-2-(2-pyridyl)ethyl]methylsulfoxide (21), is also described.
- 社団法人日本薬学会の論文
- 1992-11-25
著者
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植田 育男
Institute Of Scientific And Industrial Reseach Osaka University
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植田 育男
The Institute of Scientific and Industrial Research, Osaka University
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畠中 稔
The Institute of Scientific and Industrial Research, Osaka University
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河野 富一
The Institute of Scientific and Industrial Research, Osaka University
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栗本 正子
The Institute of Scientific and Industrial Research, Osaka University
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栗本 正子
The Institute Of Scientific And Industrial Research Osaka University
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畠中 稔
The Institute Of Scientific And Industrial Research Osaka University
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河野 富一
The Institute Of Scientific And Industrial Research Osaka University
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