Synthesis and Pharmacological Properties of N-[3-{3-(1-Piperidinylmethyl)phenoxy}propyl]-2-(2-hydroxyethylthio)acetamide and Related Compounds as Antiulcer Agents.I

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概要

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• N-Phenoxypropylacetamide derivatives were prepared and tested for antiulcer activity. These compounds exhibited both gastric acid antisecretory and cytoprotective properties. Structure-activity studies led to the identification of N-[3-{-(1-piperidinylmethyl)phenoxy}propyl]-2-(2-hydroxyethylthio)acetamide (8), which was selected for further development and clinical evaluation.

• 社団法人日本薬学会の論文
• 1990-11-25

著者

• 植田 育男

  Institute Of Scientific And Industrial Reseach Osaka University

• 新井 平八郎

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• 植田 育男

  The Institute of Scientific and Industrial Research, Osaka University

• 石井 克幸

  The Institute of Scientific and Industrial Research, Osaka University

• 畠中 稔

  The Institute of Scientific and Industrial Research, Osaka University

• 新井 平八郎

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• 精木 雅雄

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.

• 篠崎 勝男

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• 畠中 稔

  The Institute Of Scientific And Industrial Research Osaka University

• 石井 克幸

  The Institute Of Scientific And Industrial Research Osaka University

• 篠崎 勝男

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• 精木 雅雄

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

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