Studies on Pyridazines. XXVI. The Reaction of Substituted N-Acetyliminopyridazinium Ylides with Benzyne
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概要
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Reaction of N-acetyliminopyridazinium ylide (3) with benzyne afforded 1,3-dipolarcycloadduct (4). Photolysis of the cycloadduct (4), having alkoxy group in the 3-position of the pyridazine ring, afforded α-alkoxynaphthalene (5), and 3-(2-acetoamidophenyl) pyridazine (7). Photolysis of 4a did not give naphthalene, but afforded indazolo [2,3-b] pyridazine (6). Reaction of 4 with base afforded 3-vinylindazole (8). indazolo [2,3-b]4,5-dihydropyridazine (9). Reaction of 2H-pyridazinone 1-oxide (22) with benzyne afforded the 1,3-cycloadduct (23), followed by fission of N-O bond to give pyridazinone substituted with 2-hydroxyphenyl group (24). The reaction mechanisms are also discussed.
- 社団法人日本薬学会の論文
- 1977-01-25
著者
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井下 田浩
School of Pharmaceutical Sciences, Showa University
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新井 平八郎
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,
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新井 平八郎
School of Pharmaceutical Sciences, Showa University
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新井 平八郎
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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長谷川 博司
School of Pharmaceutical Sciences, Showa University
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井下 田浩
School Of Pharmaceutical Sciences Showa University
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長谷川 博司
School Of Pharmaceutical Sciences Showa University
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