Photo-oxygenation of 1H-1,2-Diazepine and Azepine Derivatives : Formation and Some Reactions of Their Epidioxides

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概要

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• The photo-sensitized oxygenation of 1,2-diazepines (1 and 12) and azepine (17) results in the formation of the corresponding relatively stable epidioxides (2,13,and 18). The dioxides (2) react with potassium hydroxide to give the epoxy-ketones (10) and with methanol to give the solvent adducts (11), probably via the intermediates (8 and 9). Treatment of 13 with alumina gives the hydroxy-epoxide (15), which is converted to the epoxy-diazepinone (16) by an alkali treatment. However, a similar treatment of 18 with bases gives only N-ethoxycarbonylaniline (19) and does not give any other characterized products.

• 社団法人日本薬学会の論文
• 1977-10-25

著者

• 井下田 浩

  School of Pharmaceutical Sciences, Showa University

• 井下 田浩

  School of Pharmaceutical Sciences, Showa University

• 新井 平八郎

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 新井 平八郎

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• 井下田 浩

  School Of Pharmaceutical Sciences Showa University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 長谷川 博司

  School of Pharmaceutical Sciences, Showa University

• 井下 田浩

  School Of Pharmaceutical Sciences Showa University

• 長谷川 博司

  School Of Pharmaceutical Sciences Showa University

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