Studies on Pyridazines. X. Reactivity of 3-Hydroxypyridazine 1-Oxides. (2). Halogenation and Nitration of 3-Hydroxypyridazine 1-Oxides

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概要

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• 3-Hydroxypyridazine 1-oxide (I) and its methyl homologs (II), (III), and (IV) were submitted to electrophilic substitutions such as nitration and halogenation. Due to the additional polar effect of both N-oxide and hydroxyl groups, introduction of nitro group and halogen in 4-and/or 6-positions was successfully concluded. By heating with potassium hydrosulfide, nucleophilic substitution of the brominated compounds (XXXI and XXXVI) was also carried out, affording mercapto compounds (XXXII and XXXVII).

• 社団法人日本薬学会の論文
• 1969-04-25

著者

• 井下田 浩

  School of Pharmaceutical Sciences, Showa University

• 土屋 隆

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 関屋 明子

  School Of Pharmaceutical Sciences Showa University

• 中島 むつみ

  School of Pharmaceutical Sciences, Showa University

• 熊木 洋子

  School of Pharmaceutical Sciences, Showa University

• 中井 淑子

  School of Pharmaceutical Sciences, Showa University

• 野島 時世

  School of Pharmaceutical Sciences, Showa University

• 井下田 浩

  School Of Pharmaceutical Sciences Showa University

• 中井 淑子

  School Of Pharmaceutical Sciences Showa University

• 熊木 洋子

  School Of Pharmaceutical Sciences Showa University

• 野島 時世

  School Of Pharmaceutical Sciences Showa University

• 中島 むつみ

  School Of Pharmaceutical Sciences Showa University

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