SYNTHESIS OF FULLY UNSATURATED MONOCYCLIC 1,2,5-TRIAZEPINES FROM 4-AZIDOPYRIDAZINES

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概要

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• Photolysis of the 3-methoxy-4-azidopyridazines (1__〜) in the presence of a base such as methoxide ion and diethylamine resulted in ring-expansion to form the corresponding unstable 1H-1,2,5-trizaepines (3__〜 and 4__〜), which were tautomerized to the relatively stable 4H-isomers 5__〜 and 6__〜 by further treatment with sodium methoxide. Treatment of the 1H-triazepines (3__〜 and 4__〜) with acetyl chloride in pyridine gave the stable 1-acetyl-1H-1,2,5-tirazepines (7__〜 and 8__〜). The products 5-8__〜 are the first examples of isolated 1,2,5-triazepines.

• 社団法人日本薬学会の論文
• 1988-10-25

著者

• 沢西 啓之

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 土屋 隆

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 沢西 啓之

  School of Pharmacy, Hokuriku University

• 斉藤 修一

  School of Pharmacy, Hokuriku University

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 斉藤 修一

  School Of Pharmacy Hokuriku University

関連論文

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