Photochemical and Thermal Ring Transformations of 8-Oxa-3,4-diaza- and 3,4,8-Triazatricyclo[5.1.0.0^<2,6>]oct-4-enes

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概要

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• Photolysis of the 8-oxa-3,4-diazatricyclo[5.1.0.0.^<2,6>]oct-4-enes (17) prepared from the 1,2-diazepines (9) via five steps resulted in a ring transformation to give the 2,3-diazabicyclo[3.1.0]hex-3-enes (20), whereas the 8-aza analogues (18) gave the 2-amino-3-cyano-5-azabicyclo[2.1.0]pentanes (23) by cleavage of the N-N bond. On the other hand, flash vacuum pyrolysis of the 8-oxa compounds 17 resulted in rearrangement to give the 1-amino-2-formylpyrroles (27), presumably via the expected 1,4,5-oxadiazocines (29), whereas the 8-aza compounds 18 gave the 3a, 6a-dihydro-pyrrolo[2,3-c]pyrazoles (33) through a different type of rearrangement.

• 公益社団法人日本薬学会の論文
• 1988-08-25

著者

• 土屋 隆

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 栗田 城治

  School of Pharmacy, Hokuriku University

• 栗田 城治

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 酒井 弘一

  School of Pharmacy, Hokuriku University

• 栗田 城治

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 酒井 弘一

  School Of Pharmacy Hokuriku University

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