Studies on Diazepines. IV. 3H-1,2-Benzodiazepines
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概要
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The previously unknown 3H-1,2- (5), 3-acetoxy-3H-1,2- (6), and 3-methoxy-3H-1,2-(7) benzodiazepines were prepared from the 1H-1,2-benzodiazepines (1) in high yields and the energy barriers to ring inversion for the 3H-diazepines (5) were estimated from nuclear magnetic resonance spectral data. Treatment of 5 with both bases and acids resulted in the tautomerization to give the 1H-isomers (1). However, the 3H-diazepines (5) gave 3-vinylindazoles (8 or 9) by thermolysis and gave the indazoles (8 or 9) and indenes (10) by photolysis in good yields, probably via the diradical (11) or the tetracyclic intermediates (12).
- 公益社団法人日本薬学会の論文
- 1978-06-25
著者
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土屋 隆
School of Pharmacy, Hokuriku University
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栗田 城治
School of Pharmacy, Hokuriku University
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土屋 隆
Faculty Of Pharmaceutical Sciences Hokuriku University
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栗田 城治
Faculty Of Pharmaceutical Sciences Hokuriku University
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