Studies on Pyridazines. XXIII. Synthesis of N-Substituted 1,4-Dihydropyridazines

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概要

• 論文の詳細を見る

• 1-Methylpyridazinium salts, derived from pyridazines (Ia-f), were reduced with sodium borohydride to give the corresponding 1-methyl-1,6-dihydropyridazines (IIa-f) in 40-60% yields. Then, pyridazines (I) were reduced with sodium borohydride in the presence of methyl chloroformate to afford 1-methoxycarbonyl-1,6-dihydropyridazines (IV) and their 1,4-isomers (V), in total 35-65% yields, ratio of which depended on the kinds of the substituents.

• 社団法人日本薬学会の論文
• 1974-12-25

著者

• 井下田 浩

  School of Pharmaceutical Sciences, Showa University

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 井下田 浩

  School Of Pharmaceutical Sciences Showa University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 金子 千里

  School of Pharmaceutical Sciences, Showa University

• 金子 千里

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 金子 千里

  Research Laboratory Minophagen Pharmaceutical Co.

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