Studies on Diazepines. XI. Oxidation of 1H-1,2-Benzodiazepines with Lead Tetraacetate : Formation and Some Reactions of Novel 5H-1,2-Benzodiazepines

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概要

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• Treatment of 1H-1,2-benzodiazepines having an electron-withdrawing group such as methoxycarbonyl or cyano in the 3-position with lead tetraacetate resulted in the formation of the corresponding 5-acetoxy-5H-1,2-benzodiazepines, which are the first reported examples of 5H-1,2-benzodiazepines. The 5H-diazepines, on treatment with base, underwent tautomerization to the 1H-isomers, and on photolysis gave 3-acetoxyindole via the tricyclic valence isomers. Furthermore, treatment of a 5H-diazepine with methanol or acetic acid gave the corresponding 4-methoxy- or 4-acetoxy-4,5-dihydro-1H-1,2-benzodiazepine, respectively, by 1,4-addition of the reagent.

• 公益社団法人日本薬学会の論文
• 1980-06-25

著者

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 栗田 城治

  School of Pharmacy, Hokuriku University

• 栗田 城治

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 栗田 城治

  Faculty Of Pharmaceutical Sciences Hokuriku University

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