Thermal Rearrangements of Cyclic Amine Ylides. III. Intramolecular Cyclization of 2-Ethynylpyridine N-Imides to 3-Azaindolizine Derivatives

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概要

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• Treatment of the N-aminopyridinium salts (5a-e) prepared from 2-ethynylpyridines (4) with potassium carbonate resulted in an intramolecular cyclization to give the corresponding 3-azaindolizines (6) (pyrazolo [2,3-a] pyridines), presumably via the ionic intermediates (8) and (9). Similarly, pyrazolo [2,3-a] quinolines (13a-c), pyrazolo [3,2-a] isoquinolines (16a-c), and pyrazolo [2,3-b] isoquinolines (19a-c) were obtained from the corresponding ethynylquinolines (11) or ethynylisoquinolines (14,17) via the N-amino salts (12,15,or 18).

• 公益社団法人日本薬学会の論文
• 1983-12-25

著者

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 指田 春喜

  School of Pharmacy, Hokuriku University

• 指田 春喜

  北陸大学薬学部

• 指田 春喜

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 此下 亜里

  School of Pharmacy, Hokuriku University

• 此下 亜里

  School Of Pharmacy Hokuriku University

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