Studies on Pyridazines. XXI. Reaction of 1-Methylpyridazinium Salts with Potassium Cyanide

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概要

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• The reactions of the methosulfates of pyridazines with KCN were carried out. Pyridazine (Ia), 3-methyl-and 3-methoxy-pyridazine (Ib and Ic) afforded two kinds of dimers (II and III), respectively. 3-Phenylpyridazine (Ih-j) afforded 4-cyano-1,4-dihydro compounds (XIV) as main products, along with small amounts of various kinds of cyano substituted monomers. Other kinds of pyridazines (Id, f, g, and k) did not afford II, III, and XIV, but various kinds of monomers (IV, V, VI, VII, VIII, IX, XV, and XVI) in general. The mechanisms of their formations were also discussed.

• 公益社団法人日本薬学会の論文
• 1973-08-25

著者

• 井下田 浩

  School of Pharmaceutical Sciences, Showa University

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 井下田 浩

  School Of Pharmaceutical Sciences Showa University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 金子 千里

  School of Pharmaceutical Sciences, Showa University

• 金子 千里

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 金子 千里

  Research Laboratory Minophagen Pharmaceutical Co.

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