A SERIES OF NOVEL ACYCLIC NUCLEOSIDES I : SYNTHESIS OF 5-AMINO-3-[(2-HYDROXYETHOXY)METHYL]-3H-IMIDAZO[4,5-d][1,3]OXAZIN-7-ONE

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概要

• 論文の詳細を見る

• A novel acyclic nucleoside (4) that N^1 of acyclovir (3) is replaced by oxygen atom was prepared. 5-Amino-1-[(2-acetoxyethoxy)methyl]-4-ethoxycarbonylimidazole (6a) was treated with ethoxycarbonyl isothiocyanate to give compound (7). Methylation of 7 with MeI afforded S-methylisothiourea derivative (8). Treatment of the latter with alkali followed by neutralization afforded 5-amino-3-[(2-hydroxyethoxy)methyl]-3H-imidazo[4,5-d][1,3]oxazin-7-one (4).

• 社団法人日本薬学会の論文
• 1989-01-25

著者

• 松本 広淳

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 水野 義久

  School Of Pharmaceutical Sciences Kitasato University

• 水野 義久

  北海道大学 薬

• 金子 千里

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 水野 義久

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 森 武夫

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 森 武夫

  Research Laboratory Minophagen Pharmaceutical Co.

• 松本 広淳

  Research Laboratory Minophagen Pharmaceutical Co.

• 金子 千里

  Research Laboratory Minophagen Pharmaceutical Co.

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