Conversion of Uridine into Isouramil Nucleosides and Related Reactions

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概要

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• Diazocoupling reaction of uracil derivatives bearing various substituents at position 5 was examined. The uracil derivatives having strong electron-releasing groups at this position were able to be coupled with a number of aryl diazonium salts to give the corresponding 6-arylazouracil derivatives. Catalytic reduction of 5-hydroxy-6-phenylazouridine (IX) prepared from 5-hydroxyuridine gave isouramil nucleoside (X). Stability of X in a pH-range (2.2-8.2) was examined and it was found that X was comparatively stable at pH ca. 3 in aqueous solution. The nucleoside having a new ring system, oxazolo (4,5-d) pyrimidine nucleoside (XII) was prepared from X.

• 公益社団法人日本薬学会の論文
• 1973-06-25

著者

• 水野 義久

  School Of Pharmaceutical Sciences Kitasato University

• 水野 義久

  Faculty Of Pharmacy Kanazawa University

• 水野 義久

  北海道大学 薬

• 池田 一芳

  The Center for Instrumental Analysis of Hokkaido University

• 池田 一芳

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 鷲見 孝彦

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 横井 国男

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 横井 国男

  Faculty Of Pharmaceutical Sciences Hokkaido University

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