Synthetic Studies of Potential Antimetabolites. XII. Synthesis of 4-Substituted 1-(β-D-Ribofuranosyl)-1H-imidazo [4,5-c] pyridines
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概要
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4-Hydroxy-1-(β-D-ribofuranosyl)-1H-imidazo [4,5-c] pyridine (3-deazainosine, XIV) was prepared by use of the corresponding 4-chloro derivative (IX) as a key intermediate. It was found that the reaction of IX with hydrazine afforded either 1-(β-D-ribofuranosyl)-1H-imidazo [4,5-c] pyridine (XIII) by de-chlorination or 4-hydrazino-1-(β-D-ribofuranosyl)-1H-imidazo [4,5-c] pyridine (X) depending upon conditions employed. Improved synthesis of IX was achieved by an adaptation of Yamaoka, Matsuda and Aso's method. In addition to X and XIV, a number of other 4-substituted ribonucleosides and nucleotides having imidazo [4,5-c] pyridine (3-deazapurine) ring system, such as XII, XV, XVI and XVII were prepared.
- 公益社団法人日本薬学会の論文
- 1968-10-25
著者
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水野 義久
School Of Pharmaceutical Sciences Kitasato University
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水野 義久
Faculty Of Pharmacy Kanazawa University
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水野 義久
北海道大学 薬
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田沢 節子
Faculty Of Pharmaceutical Sciences Hokkaido University
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影浦 邦夫
Faculty of Pharmaceutical Sciences, Hokkaido University
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影浦 邦夫
Faculty Of Pharmaceutical Sciences Hokkaido University
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