Nucleotides. III. Syntheses of Deazaadenosine 3', 5'-Cyclic Phosphates and Related Nucleotides of Biological Interest
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概要
- 論文の詳細を見る
1-Deaza-(I) and 3-deazaadenosine 3', 5'-cyclic phosphate (II) (analogs of adenosine 3', 5'-cyclic phosphate) were synthesized from N^6-acetyl-1-deazaadenosine (III) and 3-deazaadenosine (VI), respectively. In addition, a number of 1-and 3-deazaadenosine phosphates including 1-(XII) and 3-deazaadenosine 2', 3'-cyclic phosphate (XIII) were also prepared. Both VII and XIII were found to be hydrolyzed to the corresponding nucleoside 3'-phosphate by ribonuclease M. Both 1-deaza-(V) and 3-deazaadenosine 5'-phosphate (XI) were hydrolyzed by snake venom 5'-nucleotidase to the respective deazaadenosine and inorganic phosphate; the latter, however, was found to be hydrolyzed with much reduced rate.
- 社団法人日本薬学会の論文
- 1975-08-25
著者
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水野 義久
School Of Pharmaceutical Sciences Kitasato University
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水野 義久
Faculty Of Pharmacy Kanazawa University
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水野 義久
北海道大学 薬
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北野 繁
Faculty of Pharmaceutical Sciences Hokkaido University
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野村 哲士
Faculty of Pharmaceutical Sciences Hokkaido University
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