Studies on the Chemical Synthesis of Potential Antimetabolites. XXV. Synthesis of (±)-Isowillardiine by Application of a Four-Component Condensation involving 2-Picolylamine 1-Oxide and 2-Picolyl Isocyanide 1-Oxide

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概要

• 論文の詳細を見る

• 3-(2-Amino-2-carboxyethyl)uracil (racemic isowillardiine) was synthesized by the use of a four-component (aldehyde, amine, isocyanide, and carboxylic acid) condensation as the key reaction. Thus, 1-(2-picolyl 1-oxide)-3-(formylmethyl) uracil was allowed to react with 2-picolylamine 1-oxide and cyclohexyl isocyanide or 2-picolyl isocyanide 1-oxide in the presence of acetic acid in methanol to afford the corresponding condensation product, which after deblocking, gave (±)-isowillardiine in fair yield.

• 社団法人日本薬学会の論文
• 1980-09-25

著者

• 水野 義久

  School Of Pharmaceutical Sciences Kitasato University

• 水野 義久

  Faculty Of Pharmacy Kanazawa University

• 水野 義久

  北海道大学 薬

• 池田 一芳

  The Center for Instrumental Analysis of Hokkaido University

• 土田 清美

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 池田 一芳

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 土田 清美

  Faculty Of Pharmaceutical Sciences Hokkaido University

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