The Photocycloaddition Reactions of Uridine and Related Compounds with 2,3-Dimethyl-2-butene

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概要

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• The photochemical reactions of uracil and 5-fluorouracil derivatives with simple alkenes have been investigated. Photocycloaddition of uracil or 5-fluorouracil derivatives and 2,3-dimethyl-2-butene in acetone gave an enantiomeric mixture of cross cycloadducts (4,7) in moderate yields. Under similar conditions, diastereomers of 4-substituted 7,7,8,8-tetramethyl-cis-2,4-diazabicyclo[4.2.0]octane-3,5-dione nucleosides (14-17) were formed from uridine or 5-fluorouridine derivatives in good yields. The structures and stereochemistry of these cycloadducts of the nucleoside series were elucidated on the basis of the proton nuclear magnetic resonance spectra and X-ray crystallographic analysis.

• 社団法人日本薬学会の論文
• 1991-08-25

著者

• 水野 義久

  School Of Pharmaceutical Sciences Kitasato University

• 水野 義久

  北海道大学 薬

• 小倉 治夫

  School of Pharmaceutical Sciences, Kitasato University

• 高柳 弘明

  School of Pharmaceutical Sciences, Kitasato University

• 高柳 弘明

  北里大・薬

• 小倉 治夫

  北里大学

• 小倉 治夫

  School Of Pharmaceutical Sciences Kitasato University

• 伊東 常男

  School of Pahrmaceutical Sciences, Kitasato University

• 石川 一郎

  School of Pahrmaceutical Sciences, Kitasato University

• 川原 徳夫

  Hokkaido Institute of Pharmaceutical Sciences

• 高柳 弘明

  北里大学薬学部薬化学教室

• 高柳 弘明

  School Of Pharmaceutical Sciences Kitasato University

• 伊東 常男

  School Of Pharmaceutical Sciences Kitasato University

• 大島 純一

  School of Pharmaceutical Sciences, Kitasato University

• 川原 徳夫

  北海道薬大

• 石川 一郎

  School Of Pharmaceutical Sciences Kitasato University

• 大島 純一

  School Of Pharmaceutical Sciences Kitasato University

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