A New Protecting Group. IV. Syntheses of Several (2-Picolyl 1-oxide) thio Derivatives by Use of a New Thiol Group Reagent : 2-Picolylchloride 1-Oxide
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概要
- 論文の詳細を見る
Alkylation of the thiols, p-thiocresol, 4-thiouridine, 4-thiouracil, 2-mercaptoinosine, cysteine, and glutathione with 2-picolyl chloride 1-oxide (15) afforded the corresponding 2-picolyl 1-oxide derivatives (6-14) in fair to good yields even in aqueous solution. Especially, this new thiol reagent was found to work well with 4-thiouridine and glutathione. 1-Oxido-2-picolylthio-derivative (8) was subjected to deblocking of the protecting group. Recovery of 2', 3'-O-isopropylidene 4-thiouridine (19) after deblocking was found to be quite satisfactory (79.2% yield).
- 公益社団法人日本薬学会の論文
- 1974-12-25
著者
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水野 義久
School Of Pharmaceutical Sciences Kitasato University
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水野 義久
Faculty Of Pharmacy Kanazawa University
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水野 義久
北海道大学 薬
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池田 一芳
The Center for Instrumental Analysis of Hokkaido University
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池田 一芳
Faculty of Pharmaceutical Sciences, Hokkaido University
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