Studies on the Chemical Synthesis of Potential Antimetabolites. XXIV. The Synthesis and Antitumor Activities of p-Tosylhydrazones of 2-Formylpyridine 1-Oxides and 2-Formylazoles 3-Oxides

スポンサーリンク

概要

• 論文の詳細を見る

• We have developed a new method for the synthesis of 2-formyl-thiazole 3-oxide and 2-formyl-4-methylthiopyridine 1-oxide. Several new p-tosylhydrazones of pyridine, thiazole and imidazole derivatives were prepared. It was found that some of the hydrazones of the pyridine 1-oxides series were active in vivo against ascites sarcoma 180,whereas p-tosylhydrazones of the azole-N-oxide series were less active or inactive.

• 社団法人日本薬学会の論文
• 1980-05-25

著者

• 水野 義久

  School Of Pharmaceutical Sciences Kitasato University

• 水野 義久

  北海道大学 薬

• 高橋 昭

  Faculty Of Pharmaceutical Sciences Tohoku University

• 遠藤 武

  Fuji Chemical Industry Co. Ltd.,

• 榑谷 和男

  National Cancer Center Research Institute

• 飯郷 正明

  National Cancer Center Research Institute

• 星昭 夫

  国立がんセンター研究所薬効試験部

• 榑谷 和男

  Pharmacology Division, National Cancer Center Research Institute

• 遠藤 武

  Fuji Chemical Industry Co. Ltd.

• 榑谷 和男

  Pharmacology Division National Cancer Center Research Institute

• 槫谷 和男

  Pharmacology Division National Cancer Center Research Institute

• Iigo M

  National Cancer Center Research Institute

関連論文

• Pharmacokineticsにもとづいたmother compoundとそのanalogueの抗腫瘍活性の比較の試み : 非小細胞肺癌と小細胞肺癌に対するプラチナ化合物の検討
• 3.ビタミンB_補酵素のアデニン部修飾アナログの合成と補酵素機能(第293回会議研究発表要旨,ビタミンB研究委員会)
• Revised Structures of Flavidulos, Constituents of Lactarius flavidulus IMAI, and the Structure of Flavidulol D
• Chirality of the 3-Hydroxy-3-methylglutaric Acid Moiety of Fasciculic Acid A, a Calmodulin Antagonist Isolated from Naematoloma fasciculare
• Russuphelins B, C, D, E and F, New Cytotoxic Substances from the Mushroom Russula subnigricans HONGO
• Revised Structure and Stereochemistry of Hypothemycin
• 5-Lipoxygenase Inhibitors Isolated from the Mushroom Boletopsis leucomelas (PERS.) FAYOD
• Russuphelin A, a New Cytotoxic Substane from the Mushroom Russula subnigricans HONGO
• Repandiol, a New Cytotoxic Diepoxide from the Mushrooms Hydnum repandum and H. repandum var. album
• Isolation of 1-β-D-Arabinofuranosylcytosine from the Mushroom Xerocomus nigromaculatus HONGO
• Fasciculic Acids A, B and C as Calmodulin Antagonists from the Mushroom Naematoloma fasciculare
• 薬理活性物質 (キノコ類からの生物活性物質の開発と利用)
• Studies on the Constituents of Polyporus dispansus and P. confluens
• The Constituents of Lactarius flavidulus IMAI
• Antifungal Properties of Solanum Alkaloids(Biological,Chemical)
• Solanum Alkaloids as Inhibitors of Enzymatic Conversion of Dihydrolanosterol into Cholesterol(Biological,Chemical)
• Chemical and Chemotaxonomical Studies of Ferns. XXXIX. Chemical Studies on the Constituents of Pteris bella TAGAWA and Pteridium aquilinum subsp. wightianum (WALL) SHICH
• Protecting Groups in Nucleosides and Nucleotides Synthesis. VIII. Synthesis of (4-Substituted 2-Picolyl 1-Oxide) halides and 2'-and 3'-O-(4-Substituted-2-picolyl 1-Oxide) nucleosides
• Studies on the Chemical Synthesis of Potential Antimetabolites. XXIV. The Synthesis and Antitumor Activities of p-Tosylhydrazones of 2-Formylpyridine 1-Oxides and 2-Formylazoles 3-Oxides
• Metabolites of 5-^3H-Cyclocytidine in Monkeys Given Single Intravenous Injection
• A Facile Method for Synthesis of N-Acyloxymethyl-5-fluorouracils, as a Class of Antitumor Agents(Medicinal Chemistry,Chemical)
• 環状ヒドラジド構造を含む複素環化合物の合成とその抗腫瘍性について
• Improved Procedures for the Syntheses of Pyrido- and Pyrrolo[2,3-d]pyrimidines, and Ribosides Thereof
• 5-Fluorouracil Derivatives. X. : Synthesis and Antitumor Activities of α-Alkoxyalkyl-5-fluorouracils
• 5-Fluorouracil Derivatives. IX. Synthesis and Antitumor Activities of (Alkylthio) carbonyl-5-fluorouracils
• HTCAからみた肺癌の原発巣と転移巣の薬剤感受性の違い
• 82 切除肺癌のColoney assayの成績
• ロ-32 切除肺癌のColony assayとその結果に基いた術後化学療法の試み
• Effect of centrophenoxine on cyclophosphamide contration in blood
• Inhibition by Cyclocytidine of Nucleic Acid Biosynthesis in Cultured Cells (L5178Y)
• Specific Inhibition of DNA Synthesis by Cyclocytidine
• Inhibition of Guanine Deaminase with Derivatives of Imidazole
• Inhibition of Guanine Deaminase with Derivatives of 5-Amino-4-imidazolecarboxamide
• Enhancement of Antitumor Activity of Cyclophosphamide with Imipramine
• ヒト肺小細胞癌培養細胞株のin vitro抗癌剤感受性試験
• 112 Recombinant Human Tumor Necrosis Factor(rHu-TNF)のヒト肺癌培養細胞株に対する抗腫瘍効果の検討 : HTCAを用いて
• ロ-31 原発性肺癌におけるHuman Tumor Colony-forming Assay(Human Tumor Stem Cell Assay)と臨床効果との相関性について
• The Photocycloaddition Reactions of Uridine and Related Compounds with 2,3-Dimethyl-2-butene
• Syntheses of Some Tricyclic Heterocycles from 5,6-Diamino-1,3-dimethyluracil
• 83 肺癌に対するHTCAを用いたBioassayによるCisplatin血中濃度の測定と臨床効果 : 投与方法による検討
• 肺癌におけるHuman Tumor Clonogenic Cell Assay(HTCA)と臨床効果との相関
• 3.Human tumor in vitro colony assayにもとづき化学療法を行った胸水型肺腺癌の1例(第76回日本肺癌学会関東支部会)
• cDDPによるNK活性の変動(steroid hormone併用の問題点) : 関東支部 : 第78回日本肺癌学会関東支部会
• 387 原発性肺癌に対するhuman recombinant IL-2投与時の血中NK活性の変動について
• 108 ヒト肺癌培養細胞株に対するCisplatinとCarboplatinの抗腫瘍活性の検討
• Synthesis of 2,4-Dithiouridine and 2-Thiocytidines
• Synthetic Studies of Potential Antimetabolites. XI. Syntheses of β-D-Pentofuranosyl-5-methylcytosines
• テレフタール酸の代謝(第2報) : 血漿内テレフタール酸の消長および生物学的半減期
• Studies on the Chemical Constituents of Rutaceous Plants. LX. Development of a Versatile Method for Syntheses of the Antitumor Benzo [c] phenanthridine Alkaloids. (9). Efficient Syntheses and Antitumor Activities of Nitidine and Related Nonphenolic Benzo
• Antitumor Activity of Shikonin, Alkannin and Their Derivatives. II. X-Ray Analysis of Cyclo-alkannin Leucoacetate, Tautomerism of Alkannin and Cyclo-alkannin and Antitumor Activity of Alkannin Derivatives
• Mode of Action of 5-Fluorouridine 5'-Phosphate in Vivo and in Vitro
• Antitumor Activity of 1-Alkylcarbamoyl Derivatives of 5-Fluorouracil against L1210 Leukemia
• Distribution of Cyclocytidine in Tissues
• Autoradiographic Study on the Distribution of Cyclocytidine in Mice
• Resistance of Cyclocytidine to Cytidine Deaminase
• Studies on Antitumor Agents. III. Metabolites of 5 (4)-Amino-4 (5)-imidazolethiocarboxamide Derivatives in Urine
• Studies on Antitumor Agents. I. Antitumor Activity of 5 (4)-Amino-4 (5)-imidazolecarboxamide Analogs
• Toxicity of Terephthalic Acid
• Syntheses of 7-Alkyl-1,3,6-trimethylpyrrolo[2,3-d]pyrimidines and 4-Alkylamino-2,5-dimethyl-2,3-dihydrofuro[3,2-e]pyrimidines
• A Series of Novel Acyclic Nucleosides. IV. Synthesis of N^1-Sulfur Analogues of Acyclovir, Directed toward Improved Antivial Activities
• A SERIES OF NOVEL ACYCLIC NUCLEOSIDES I : SYNTHESIS OF 5-AMINO-3-[(2-HYDROXYETHOXY)METHYL]-3H-IMIDAZO[4,5-d][1,3]OXAZIN-7-ONE
• Reactions of 1-(2-Acetoxyethoxy)methyl-5-amino-4-cyanoimidazole with Isothiocyanates
• A Convenient Synthesis of 9-(2-Hydroxyethoxymethyl)guanine (Acyclovir) and Related Compounds
• Studies Directed toward the Total Synthesis of Sinefungin. I. Synthesis of 4-(5'-Deoxyuridin-5'-yl)-4-nitrobutyronitrile, 4-(5'-Deoxyadenosin-5'-yl)-4-nitrobutyramide and Closely Related Nucleosides
• Studies on the Chemical Synthesis of Potential Antimetabolites. XXXIV. Apparent Discrepancy among Reported Proton Nuclear Magnetic Resonance Spectra of 3-Deazaadenosine Is Actually a Reflection of a Difference in Molecular Species
• Synthesis of (23R)-Calcidiol Lactone (25-Hydroxyvitamin D_3 26,23-Lactone)
• Studies on the Chemical Synthesis of Potential Antimetabolites. XXV. Synthesis of (±)-Isowillardiine by Application of a Four-Component Condensation involving 2-Picolylamine 1-Oxide and 2-Picolyl Isocyanide 1-Oxide
• 支部長を理事に併任させ理事会の重要な任務を分担させたら
• Nucleotides. VII. A Procedure for the Preparation of Diribonucleoside Monophosphates having Natural Linkage
• 8 生理活性アミノアシルユラシル類(イソビラルジイン、ポリオキシン)の合成研究
• Syntheses of Potential Antimetabolites. XX. Syntheses of 5-Carbomethoxymethyl-and 5-Methylaminomethyl-2-thiouridine (The "First Letters"of Some Anticodons) and Closely Related Nucleosides from Uridine
• Nucleotides. III. Syntheses of Deazaadenosine 3', 5'-Cyclic Phosphates and Related Nucleotides of Biological Interest
• 肺癌の継代培養細胞及び初代培養細胞に対するMTT colorimetric assay を用いた新しい抗癌剤感受性試験の試み
• MINI-hybrid assayによるヒト肺癌培養細胞に対する抗癌剤感受性テスト
• 抗腫瘍薬とヒト腫瘍細胞の薬剤感受性
• 107 HTCAを用いた肺癌培養細胞株に対するシスプラチン、ビンデシン、エトポシドの併用効果の検討 : simultaneous or sequentail use
• 肺癌におけるColony assayの意義(臨床)
• 肺がんにおけるColony Assayの成績(基礎)
• 肺癌におけるcolony assayの成績(基礎)
• Syntheses of Potential Antimetabolites. XVII. New Type of Cyclo- and Keto-sugar-nucleosides. 7-(5-O-Trityl-2,3-dideoxy-2-oxo-α-D-pentofuranosyl)-and 5'-O-Trityl-3', 6-anhydro-7-α-D-arabinofuranosylhypoxanthine
• Synthesis of a Potential Antitumor Agent : 4-(β-D-Ribofuranosyl)-4,5,6,7-tetrahydrothiazolo [4,5-d] pyrimidine-5,7-dione (Thioanalog of 3-Isoxanthosine)
• Structural Elucidation of Tubercidin
• Potential Antimetabolites. VI. An Improved Synthesis of 2-β-D-Ribofuranosyl-as-triazine-3,5 (2H, 4H)-dione (6-Azauridine).
• Potential Antimetabolites. II. Chemical Synthesis of 6-Azacytidine.
• Potential Antimetabolites. I. Selective Thiation of Uracil and 1,2,4-Triazine-3,5 (2H, 4H)-dione (6-Azauracil).
• Distribution of Terephthalic Acid in Tissues
• Hydrogen Fluoride as an Agent in Organic Reactions. I. Degradation of Polynucleotides with Liquid Hydrogen Fluoride
• Selective Acylation of the Amino or the Primary Hydroxyl Group of Cytidine
• Synthetic Studies of Potential Antimetabolites. VII. Evidences that the supposed 1-β-D-Ribofuranosyl-1H-imidazo [4,5-b] pyridine is actually 3-β-D-Ribofuranosyl-3H-imidazo [4,5-b] pyridine (1-Deazapurine Ribofuranoside)
• A New Protecting Group. IV. Syntheses of Several (2-Picolyl 1-oxide) thio Derivatives by Use of a New Thiol Group Reagent : 2-Picolylchloride 1-Oxide
• Synthesis of 2,4-Dithiouridine and 2-Thiocytidine
• Interactions between Synthetic Nucleotide Analogs and Snake Venom 5'-Nucleotidase
• A New and Convenient Synthesis of 1-O-Acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose from Guanosine ; Some Observations on Solvolysis of 2', 3', 5'-Tri-O-benzoylguanosine
• Synthetic Studies of Potential Antimetabolites. XII. Synthesis of 4-Substituted 1-(β-D-Ribofuranosyl)-1H-imidazo [4,5-c] pyridines
• 薬理活性物質
• Potential Antimetabolites. V. The Syntheses of 4-, 5-, and 6-Nitrobenzimidazole Ribofuranosides.
• α-ピコリル1-オキシド基を用いる有機合成
• Conversion of Uridine into Isouramil Nucleosides and Related Reactions
• Reactions of Uracil Derivatives with Phenylhydrazine

もっと見る 閉じる

スポンサーリンク