Enhancement of Antitumor Activity of Cyclophosphamide with Imipramine

概要

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Potentiation of cyclophosphamide activity by non antitumor agents which might affect the liver microsomal enzymes, was examined with Sarcoma 180. That activity of low dose, only 24% inhibition in tumor growth, was enhanced to 94% by imipramine. But any potentiation was not shown by phenobarbital, pentobarbital, isoniazid, meprobamate or glutethimide. The cyclophosphamide activating enzymes in liver were enhanced by phenobarbital but not imipramine treatment, besides both concentrations of the activated and intact cyclophosphamide in blood were not elevated and not maintained by the latter. Nigrosine stainability of the tumor cell was stimulated by less than 1 mg/ml of imipramine in vitro, that was a different phenomenon from the surface activity of Tween 80. One of the possible couses for enhancement in antitumor activity of cyclophosphamide by imipramine was considered to be the stimulation of membrane permeability.
社団法人日本薬学会の論文
1969-08-25