Inhibition by Cyclocytidine of Nucleic Acid Biosynthesis in Cultured Cells (L5178Y)
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概要
- 論文の詳細を見る
Mechanism of action of cyclocytidine was examined in cultured cells (L5178Y). Cyclocytidine was active against the leukemia in vitro as well as in vivo and its IC_<50> was 0.041μg/ml, whereas that for aracytidine was 0.023μg/ml. This compound was also inhibited the thymidine incorporation into DNA and its IC_<50> was 110μg/ml, while that was 1.1μg/ml for aracytidine. Cyclocytidine itself was therefore considered to have no direct inhibitory effect. Since cyclocytidine seems to act in vitro as aracytidine after transformation, the factor influencing the transformation was examined and revealed to be only pH of the aqueous solution. Ratio of the transformantion under physiological conditions (pH7.3,37°) was about 30 and 70% after 4 and 24 hr incubations, respectively.
- 社団法人日本薬学会の論文
- 1973-07-25
著者
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金井 貞
Research Labolatories, Kohjin Co., Ltd.
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吉田 光二
National Cancer Center Research Institute
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市野 元信
Research Laboratories, Kohjin Co., Ltd.
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星昭 夫
国立がんセンター研究所薬効試験部
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榑谷 和男
Pharmacology Division, National Cancer Center Research Institute
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榑谷 和男
Pharmacology Division National Cancer Center Research Institute
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槫谷 和男
Pharmacology Division National Cancer Center Research Institute
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金井 貞
Research Labolatories Kohjin Co. Ltd.
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市野 元信
Research Laboratories Kohjin Company Ltd.:(present Address)kitasato Biochemical Laboratories Bristol
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