テレフタール酸の血漿内サイアミン濃度に及ぼす影響 : 1. 血漿内サイアミン濃度増加及び持続性
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概要
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Tetracycline-type antibiotics were potentiated by terephthalic acid (TPA) and the ac-celeration of body growth was observed in the fowl 1, 4, 9-11). Further, the TPA contained diet without antibiotics has the same effect on faccilitation of body weight gain and the feed conversion ratios were lowered in the fowl 5, 6). From these interesting function of TPA, we-planned to clarify how TPA effects on the plasma nutrients concentration. In this study, plasma thiamine contents were determined.Control group (25 fowls) was fed with the basal diet and TPA group (25 fowls) was fed with the diet containing TPA (0.5%) for 20 days. Followed by the oral administration of thiamine (1mg/kg of body weight), blood was collected from the carotid with a heparinized. syringe at 0, 4th, 24th and 48th hour, from 10, 5, 5 and 5 fowls respectively. Blood was. centrifuged and plasma was used for thiamine determination.Thiamine level in each case is tabulated in Table 1. The increased rate of TPA group, was 1.7 times higher at 4th hour and 3.7 times higher at 24th hour than control group. The increased thiamine content by administration of the control group successively decreased and reached normal level at 48th hour, but that of TPA group was kept still higher. After all, it is studied that the plasma thiamine level in all cases of TPA group were higher than that:of control group.This effect of the TPA was observed not only in the fowl but also in the rat. The increased rate of TPA group was 1.4 times higher at 4th hour and 3.0 times higher at 24th hour than control group (Table 2).In conclusion, plasma thiamine level in the TPA group of the fowl was elevated and kept for 48 hours by single administration of thiamine and this elevation was also occured in the rat.Biological half-lives of thiamine (per os) in control and TPA groups were estimated, but significant difference was not observed (Fig. 1). This result suggests that the primary mechanism of TPAs effect on the elevation of plasma thiamine content seems to be concerned with the absorption of thiamine across the gastrointestinal wall rather than with the kidney threshold for the excretion of thiamine.
- 社団法人 日本畜産学会の論文
著者
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榑谷 和男
Pharmacology Division National Cancer Center Research Institute
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榑谷 和男
千葉大学藥学部
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星 昭夫
千葉大学藥学部
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平山 八彦
日本大学農獣医学部
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- テレフタール酸の血漿内サイアミン濃度に及ぼす影響 : 1. 血漿内サイアミン濃度増加及び持続性