Studies on Antitumor Agents. III. Metabolites of 5 (4)-Amino-4 (5)-imidazolethiocarboxamide Derivatives in Urine
スポンサーリンク
概要
- 論文の詳細を見る
5 (4)-Formamido-4 (5)-imidazolethiocarboxamide and 1-β-D-ribofuranosyl-5-amino-4-imidazolethiocarboxamide were active against various tumors. Their metabolites in urine of mice were determiend with thin-layer chromatography. 5 (4)-Amino-4 (5)-imidazolethiocarboxamide, which was inactive against Nakahara-Fukuoka sarcoma, was excreted intact and 6-mercaptopurine was not found in urine after the intraperitoneal injection. On the other hand, the large quantity of 6-mercaptopurine was found in urine after the administration of 5 (4)-Formamido-4 (5)-imidazolethiocarboxamide. 1-β-D-Ribofuranosyl-5-amino-4-imidazolethiocarboxamide was mainly excreted intact, and a small quantity of 5 (4)-amino-4 (5)-imidazolethiocarboxamide and a trace amount of 6-mercaptopurine were found in urine.
- 社団法人日本薬学会の論文
- 1969-08-25
著者
-
星昭 夫
国立がんセンター研究所薬効試験部
-
榑谷 和男
Pharmacology Division, National Cancer Center Research Institute
-
星 昭夫
Pharmacology Division, National Cancer Center Research Institute
-
榑谷 和男
Pharmacology Division National Cancer Center Research Institute
-
槫谷 和男
Pharmacology Division National Cancer Center Research Institute
-
逢坂 陽子
Pharmacology Division, National Cancer Center Research Institute
-
逢坂 陽子
Pharmacology Division National Cancer Center Research Institute
関連論文
- Pharmacokineticsにもとづいたmother compoundとそのanalogueの抗腫瘍活性の比較の試み : 非小細胞肺癌と小細胞肺癌に対するプラチナ化合物の検討
- Studies on the Chemical Synthesis of Potential Antimetabolites. XXIV. The Synthesis and Antitumor Activities of p-Tosylhydrazones of 2-Formylpyridine 1-Oxides and 2-Formylazoles 3-Oxides
- Metabolites of 5-^3H-Cyclocytidine in Monkeys Given Single Intravenous Injection
- 環状ヒドラジド構造を含む複素環化合物の合成とその抗腫瘍性について
- Metabolism of Cyclocytidine and Aracytidine in Mice
- HTCAからみた肺癌の原発巣と転移巣の薬剤感受性の違い
- 82 切除肺癌のColoney assayの成績
- ロ-32 切除肺癌のColony assayとその結果に基いた術後化学療法の試み
- Effect of centrophenoxine on cyclophosphamide contration in blood
- Inhibition by Cyclocytidine of Nucleic Acid Biosynthesis in Cultured Cells (L5178Y)
- Specific Inhibition of DNA Synthesis by Cyclocytidine
- Inhibition of Guanine Deaminase with Derivatives of Imidazole
- Inhibition of Guanine Deaminase with Derivatives of 5-Amino-4-imidazolecarboxamide
- Enhancement of Antitumor Activity of Cyclophosphamide with Imipramine
- ヒト肺小細胞癌培養細胞株のin vitro抗癌剤感受性試験
- 112 Recombinant Human Tumor Necrosis Factor(rHu-TNF)のヒト肺癌培養細胞株に対する抗腫瘍効果の検討 : HTCAを用いて
- ロ-31 原発性肺癌におけるHuman Tumor Colony-forming Assay(Human Tumor Stem Cell Assay)と臨床効果との相関性について
- 83 肺癌に対するHTCAを用いたBioassayによるCisplatin血中濃度の測定と臨床効果 : 投与方法による検討
- 肺癌におけるHuman Tumor Clonogenic Cell Assay(HTCA)と臨床効果との相関
- 3.Human tumor in vitro colony assayにもとづき化学療法を行った胸水型肺腺癌の1例(第76回日本肺癌学会関東支部会)
- cDDPによるNK活性の変動(steroid hormone併用の問題点) : 関東支部 : 第78回日本肺癌学会関東支部会
- 387 原発性肺癌に対するhuman recombinant IL-2投与時の血中NK活性の変動について
- 108 ヒト肺癌培養細胞株に対するCisplatinとCarboplatinの抗腫瘍活性の検討
- テレフタール酸の代謝(第2報) : 血漿内テレフタール酸の消長および生物学的半減期
- Studies on the Chemical Constituents of Rutaceous Plants. LX. Development of a Versatile Method for Syntheses of the Antitumor Benzo [c] phenanthridine Alkaloids. (9). Efficient Syntheses and Antitumor Activities of Nitidine and Related Nonphenolic Benzo
- Antitumor Activity of Shikonin, Alkannin and Their Derivatives. II. X-Ray Analysis of Cyclo-alkannin Leucoacetate, Tautomerism of Alkannin and Cyclo-alkannin and Antitumor Activity of Alkannin Derivatives
- Mode of Action of 5-Fluorouridine 5'-Phosphate in Vivo and in Vitro
- Antitumor Activity of 1-Alkylcarbamoyl Derivatives of 5-Fluorouracil against L1210 Leukemia
- Distribution of Cyclocytidine in Tissues
- Autoradiographic Study on the Distribution of Cyclocytidine in Mice
- Resistance of Cyclocytidine to Cytidine Deaminase
- Studies on Antitumor Agents. III. Metabolites of 5 (4)-Amino-4 (5)-imidazolethiocarboxamide Derivatives in Urine
- Antitumor Activity of Psychotropic Drugs and Their Synergic Action with Cyclophosphamide
- Studies on Antitumor Agents. I. Antitumor Activity of 5 (4)-Amino-4 (5)-imidazolecarboxamide Analogs
- Toxicity of Terephthalic Acid
- 肺癌の継代培養細胞及び初代培養細胞に対するMTT colorimetric assay を用いた新しい抗癌剤感受性試験の試み
- MINI-hybrid assayによるヒト肺癌培養細胞に対する抗癌剤感受性テスト
- 抗腫瘍薬とヒト腫瘍細胞の薬剤感受性
- 107 HTCAを用いた肺癌培養細胞株に対するシスプラチン、ビンデシン、エトポシドの併用効果の検討 : simultaneous or sequentail use
- 肺癌におけるColony assayの意義(臨床)
- 肺がんにおけるColony Assayの成績(基礎)
- 肺癌におけるcolony assayの成績(基礎)
- Effect of Terephthalic Acid on the Activities of p-Dimethylaminoazobenzene Metabolizing Enzymes in Rat Liver
- Distribution of Terephthalic Acid in Tissues
- Effect of Terephthalic Acid on the Bound Dye Level in the Liver of Rat fed p-Dimethylaminoazobenzene.
- Metabolism of Terephthalic Acid. III. Absorption of Terephthalic Acid from Gastrointestinal Tract and Detection of Its Metabolites.
- Effect of Terephthalic Acid upon Sulfadimethoxine Contents in Blood Plasma.
- 組織内テレフタール酸含量
- テレフタール酸の血漿内サイアミン濃度に及ぼす影響 : 1. 血漿内サイアミン濃度増加及び持続性
- テレフタール酸の血漿内チアミン濃度におよぼす影響 : II. 飼料へのテレフタール酸添加量と血漿内チアミン濃度の関係