Autoradiographic Study on the Distribution of Cyclocytidine in Mice
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概要
- 論文の詳細を見る
The distribution of cyclocytidine was investigated by means of whole-body autoradiographic technique following intravenous injection in mice. Significant difference was found in the distribution pattern of radioactivity between cyclocytidine and other cytidine analogues such as aracytidine. Distribution of cyclocytidine was more localized in some organs than that of aracytidine, and was analogous to that of cytidine and not deoxycytidine. Cyclocytidine and aracytidine disappeared almost completely from the body within 24 hr. These two compounds were scarcely incorporated in acid-insoluble components in tissues within 10 min, whereas cytidine and deoxycytidine was rapidly incorporated into nucleic acids and the latter two compounds retained over 24 hr.
- 社団法人日本薬学会の論文
- 1974-10-25
著者
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飯郷 正明
National Cancer Center Research Institute
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金井 貞
Research Labolatories, Kohjin Co., Ltd.
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市野 元信
Research Laboratories, Kohjin Co., Ltd.
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星昭 夫
国立がんセンター研究所薬効試験部
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榑谷 和男
Pharmacology Division, National Cancer Center Research Institute
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榑谷 和男
Pharmacology Division National Cancer Center Research Institute
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槫谷 和男
Pharmacology Division National Cancer Center Research Institute
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Iigo M
National Cancer Center Research Institute
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金井 貞
Research Labolatories Kohjin Co. Ltd.
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市野 元信
Research Laboratories Kohjin Company Ltd.:(present Address)kitasato Biochemical Laboratories Bristol
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