Metabolism of Cyclocytidine and Aracytidine in Mice
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概要
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Rate of excretion and metabolites in urine and feces of mice after intravenous or oral administration of ^<14>C-cyclocytidine and ^<14>C-aracytidine were examined. Furthermore, absorption from gastrointestinal tract was examined. After intravenous injection, about 80% of cyclocytidine was excreted in urine within 24 hours and not in feces. Main radioactive compound in urine was intact cyclocytidine and small amount of aracytidine and arauridine were detected, while two-thirds of ^<14>C-aracytidine administered were excreted after metabolized to arauridine. A half of cyclocytidine was excreted in feces as intact when administered orally. Very small amount of cyclocytidine was excreted in expired air as CO_2. However, one-fourth of radioactivity was excreted in expired air after oral administration of ^<14>C-aracytidine. Cyclocytidine was mainly absorbed from stomach and slightly from large intestine.
- 社団法人日本薬学会の論文
- 1975-08-25
著者
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星 昭夫
National Cancer Center Research Institute
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金井 貞
Research Labolatories, Kohjin Co., Ltd.
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吉田 光二
National Cancer Center Research Institute
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槫谷 和男
Pharmacology Division, National Cancer Center Research Institute
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市野 元信
Research Laboratories, Kohjin Co., Ltd.
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榑谷 和男
Pharmacology Division, National Cancer Center Research Institute
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榑谷 和男
Pharmacology Division National Cancer Center Research Institute
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槫谷 和男
Pharmacology Division National Cancer Center Research Institute
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金井 貞
Research Labolatories Kohjin Co. Ltd.
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市野 元信
Research Laboratories Kohjin Company Ltd.:(present Address)kitasato Biochemical Laboratories Bristol
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