Metabolism of Cyclocytidine and Aracytidine in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Rate of excretion and metabolites in urine and feces of mice after intravenous or oral administration of ^<14>C-cyclocytidine and ^<14>C-aracytidine were examined. Furthermore, absorption from gastrointestinal tract was examined. After intravenous injection, about 80% of cyclocytidine was excreted in urine within 24 hours and not in feces. Main radioactive compound in urine was intact cyclocytidine and small amount of aracytidine and arauridine were detected, while two-thirds of ^<14>C-aracytidine administered were excreted after metabolized to arauridine. A half of cyclocytidine was excreted in feces as intact when administered orally. Very small amount of cyclocytidine was excreted in expired air as CO_2. However, one-fourth of radioactivity was excreted in expired air after oral administration of ^<14>C-aracytidine. Cyclocytidine was mainly absorbed from stomach and slightly from large intestine.
- 社団法人日本薬学会の論文
- 1975-08-25
著者
-
星 昭夫
National Cancer Center Research Institute
-
金井 貞
Research Labolatories, Kohjin Co., Ltd.
-
吉田 光二
National Cancer Center Research Institute
-
槫谷 和男
Pharmacology Division, National Cancer Center Research Institute
-
市野 元信
Research Laboratories, Kohjin Co., Ltd.
-
榑谷 和男
Pharmacology Division, National Cancer Center Research Institute
-
榑谷 和男
Pharmacology Division National Cancer Center Research Institute
-
槫谷 和男
Pharmacology Division National Cancer Center Research Institute
-
金井 貞
Research Labolatories Kohjin Co. Ltd.
-
市野 元信
Research Laboratories Kohjin Company Ltd.:(present Address)kitasato Biochemical Laboratories Bristol
関連論文
- Studies on the Chemical Synthesis of Potential Antimetabolites. XXIV. The Synthesis and Antitumor Activities of p-Tosylhydrazones of 2-Formylpyridine 1-Oxides and 2-Formylazoles 3-Oxides
- Metabolites of 5-^3H-Cyclocytidine in Monkeys Given Single Intravenous Injection
- 5-Fluorouracil Derivatives XX. : Synthesis and Antitumor Activity of 5'-O-Unsaturated Acyl-5-fluorouridines
- 5-Fluorouracil Dirivatives. XVII. : Synthesis and Antitumor Activity of 5'-O-Acyl-5-fluorouridines
- A Facile Method for Synthesis of N-Acyloxymethyl-5-fluorouracils, as a Class of Antitumor Agents(Medicinal Chemistry,Chemical)
- 環状ヒドラジド構造を含む複素環化合物の合成とその抗腫瘍性について
- 5-Fluorouracil Derivatives XX. : Synthesis and Antitumor Activity of 5'-O-Unsaturated Acyl-5-fluorouridines
- 5-Fluorouracil Dirivatives. XVII. : Synthesis and Antitumor Activity of 5'-O-Acyl-5-fluorouridines
- 5-Fluorouracil Derivatives. X. : Synthesis and Antitumor Activities of α-Alkoxyalkyl-5-fluorouracils
- 5-Fluorouracil Derivatives. IX. Synthesis and Antitumor Activities of (Alkylthio) carbonyl-5-fluorouracils