5-Fluorouracil Dirivatives. XVII. : Synthesis and Antitumor Activity of 5'-O-Acyl-5-fluorouridines
スポンサーリンク
概要
- 論文の詳細を見る
With the aim of diminishing the toxicity of 5-fluorouridine (1) and obtaining biologically active derivatives of 1,various kinds of 5'-O-acyl-8-fluorouridines 2 were synthesized. The antitumor activity of the compounds against L-1210 leukemia in mice was examined. The 5'-O-heptanoyl derivative 2h showed the highest antitumor activity.
- 社団法人日本薬学会の論文
- 1989-12-25
著者
-
星 昭夫
National Cancer Center Research Institute
-
尾崎 庄一郎
愛媛大工
-
秋山 隆彦
愛媛大工
-
尾崎 庄一郎
Faculty of Engineering, Ehime University
-
秋山 隆彦
Faculty of Engineering, Ehime University
-
池 祥雅
Research Center, Mitsui Toatsu Chemicals
-
森 春樹
Research Center, Mitsui Toatsu Chemicals
-
Miura Hirohito
National Food Research Institute
-
池 祥雅
Research Center Mitsui Toatsu Chemicals
-
Moriya H
Department Of Pathology Gifu University School Of Medicine
-
森 春樹
Research Center Mitsui Toatsu Chemicals
関連論文
- Metabolites of 5-^3H-Cyclocytidine in Monkeys Given Single Intravenous Injection
- Multiplex PCR法を用いた組換えトウモロコシ5系統からの組換え遺伝子の検知法
- 128(P80) イノシトールリン脂質類の合成(ポスター発表の部)
- 76 光学活性なシクリトール誘導体を不斉源として用いた不斉合成反応の開発(ポスター発表の部)
- イノシトールリン脂質の関与する情報伝達系への有機化学的アプローチ
- 5-Fluorouracil Derivatives XX. : Synthesis and Antitumor Activity of 5'-O-Unsaturated Acyl-5-fluorouridines
- 83 エナンチオ選択的アシル化による光学活性ミオ-イノシトール誘導体の調達とそれを利用するイノシトール三-および四リン酸の簡易合成(口頭発表の部)
- A SHORT STEP AND PRACTICAL SYNTHESIS OF MYO-INOSITOL 1,3,4,5-TETRAKISPHOSPHATE
- 5-Fluorouracil Dirivatives. XVII. : Synthesis and Antitumor Activity of 5'-O-Acyl-5-fluorouridines
- 66(P1-14) ミオ-イノシトールの直接的かつ効率的保護化とイノシトールリン酸類の合成(ポスター発表の部)
- 14 ミオーイノシトール1,4,5-トリリン酸およびその関連体の簡便な合成(ポスター発表の部)
- A Facile Method for Synthesis of N-Acyloxymethyl-5-fluorouracils, as a Class of Antitumor Agents(Medicinal Chemistry,Chemical)
- 60(PB1-9) アルコキシドを経由するポリホスホリル化法を利用するイノシトールリン酸類の合成(ポスター発表の部)
- 79 ミオ-イノシトールリン酸類の合成
- 5-Fluorouracil Derivatives. XI. : Synthesis of 1-Hexylcarbamoyl-5-fluorouracil Metabolites
- 5-Fluorouracil Derivatives XX. : Synthesis and Antitumor Activity of 5'-O-Unsaturated Acyl-5-fluorouridines
- 5-Fluorouracil Dirivatives. XVII. : Synthesis and Antitumor Activity of 5'-O-Acyl-5-fluorouridines
- 5-Fluorouracil Derivatives. X. : Synthesis and Antitumor Activities of α-Alkoxyalkyl-5-fluorouracils
- 5-Fluorouracil Derivatives. IX. Synthesis and Antitumor Activities of (Alkylthio) carbonyl-5-fluorouracils
- Mode of Action of 5-Fluorocytidine and 5-Fluoro-2'-deoxycytidine in L5178Y Cells in Vitro
- Metabolism of Cyclocytidine and Aracytidine in Mice
- Non-steroidal anti-inflammatory drugs inhibit cellular proliferation and upregulate cyclooxygenase-2 protein expression in endometrial cancer cells
- Preventive Effect of Juzen-taiho-to on Endometrial Carcinogenesis in Mice Is Based on Shimotsu-to Constituent(Pharmacology)
- Inhibitory Effects of Toremifene on N-Methyl-N-nitrosourea and Estradiol-17β-induced Endometrial Carcinogenesis in Mice
- Preventive Effects of Isoflavones, Genistein and Daidzein, on Estradiol-17β-related Endometrial Carcinogenesis in Mice
- Preventive Effects of Glycyrrhizae radix Extract on Estrogen-related Endometrial Carcinogenesis in Mice
- Effects of Tamoxifen on Endometrial Carcinogenesis in Mice
- Inhibitory Effects of Medroxyprogesterone Acetate on Mouse Endometrial Carcinogenesis
- The Effect of Feeding Carrots on Immunoglobulin E Production and Anaphylactic Response in Mice
- Mode of Action of 5-Fluorouridine 5'-Phosphate in Vivo and in Vitro
- ミオイノシト-ルリン酸類の合成
- 5-Fluorouracil Derivatives. IV. Synthesis of Antitumor-Active Acyloxyalkyl-5-fluorouracils
- Adhesion and Colonization of Enterohemorrhagic Escherichia coli O157 : H7 in Cecum of Mice
- Dependence of Hydrolysis of β-Lactams with a Zinc(II)-β-Lactamase Produced from Sermtia marcescens (IMP-1) on pH and Concentration of Zinc(II) Ion : Dissociation of Zn(II) from IMP-1 in Acidic Medium
- A Murine Model of Enterohemorrhagic Escherichia coli O157 : H7 Infection to Assess Immunopotentiating Activity of Drugs on Mucosal Immunity : Effect of Drugs
- Inhibition of the Metallo-β-lactamase Produced from Serratia marcescens by Thiol Compounds
- 制ガン剤と高分子
- トウモロコシからの組換え遺伝子の検知法
- Expression of leptin receptor (Ob-R) isoforms and signal transducers and activators of transcription (STATs) mRNAs in the mouse taste buds
- イノシトール ポリリン酸の合成
- イソシアナートの化学-最近の進歩
- 新規酵素阻害剤 Mannostatin A の全合成
- FXYD6, a Na,K-ATPase Regulator, Is Expressed in Type II Taste Cells